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. 2023 Jun 3;15:95. doi: 10.1186/s13148-023-01511-y

Fig. 3.

Fig. 3

DNA methylation patterns across the DMR (chr5: 112,072,926–112,073,958) overlapping the APC gene. A. The DMR (differentially methylated region) associated with the MLH1 epimutation CRCs. B. Bar plot showing mean DNA methylation levels by CRC subgroups. Error bars denote standard deviation. MLH1 epimutation group includes primary MLH1 epimutation and secondary MLH1 epimutation (c.-27C > A) CRCs. MLH1 promoter VUS group includes CRCs from two MLH1: c.-11C > T and one MLH1: c.-[28A > G; 7C > T] carriers