Fig. 6.

Discovery and validation of histopathologic gene-signature. A The KEGG enrichment of up- and down-regulated differentially expressed genes (DEGs). B The frequent distribution of histopathologic-related genes in 1000 Lasso-penalized selection and 12 genes were greater than 200 times. C AUC values for different histopathologic-related genes combination. When the combination is three, the AUC reaches the highest value (0.845). D The ROC curve for three gene combination. E The risk heatmap of UM patients in TCGA-UVM cohort. F Kaplan–Meier (K-M) curve of survival probability between high- and low-risk group in TCGA-UVM cohort. G Time dependent ROC (td-ROC) curves and corresponding AUC values in TCGA-UVM cohort. H Forest plot for meta-analysis of multiple UVM cohorts