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. 2023 Jun 3;15:96. doi: 10.1186/s13148-023-01513-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — SOMNiBUS-estimated smooth association parameters associated with methylation differences between SSc disease and controls. Parameters are shown on the logit scale for DMRs annotated to A FLT4, the top ranked autosomal DMG, located on chromosome 5; and B CHST7, the top ranked DMG located on chromosome X. Points (left y-axis) indicate the estimated smoothed coefficient value (vertical axis) at each individual CpG in the region (x-axis), and pointwise confidence intervals are shown in light gray. Structural gene annotations (right y-axis) are shown in shaded boxes: light blue (introns), lilac (exons), green (promoters and first exons; both of which are linked to transcriptional silencing)