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. Author manuscript; available in PMC: 2023 Dec 1.
Published in final edited form as: Mol Cancer Res. 2023 Jun 1;21(6):591–604. doi: 10.1158/1541-7786.MCR-22-0516

Figure 2. ESR1 mutant-specific de novo transcriptomic alterations are associated with FOXA1-RXR nexus.

Figure 2.

(A) Bar plot showing the regulatory potential of gained/lost FOXA1 peaks on ligand independent and novel target genes in T47D ESR1 Y537S and D538G cells. p values were obtained by one-tailed Kolmogorov-Smirnov test from BETA. (* p<0.05)

(B) Venn diagram showing the overlap between novel target genes and FOXA1 gained binding sites annotated genes in Oesterreich T47D ESR1 Y537S can D538G cells.

(C) Motif enrichment analysis of FOXA1 binding sites in Oesterreich T47D ESR1 WT and mutant cells. Venn diagram shows the overlap of significantly enriched motifs (E-value<0.05, obtained by Fisher’s Exact Test from MEME-Suite) in WT, Y537S and D538G cells. The top shared motifs and mutant-enriched motifs were shown on each side, motifs of RXR subtypes were highlighted.

(D) Venn diagram showing the overlap of significantly enriched pathways (p-value<0.05, obtained by Fisher’s Exact Test from IPA) in genes with gained FOXA1 binding sites between T47D ESR1 Y537S and D538G cells. Among the 27 overlapped pathways, 3 RXR-related pathways were highlighted on the right side.