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. Author manuscript; available in PMC: 2023 Dec 2.
Published in final edited form as: Cancer Res. 2023 Jun 2;83(11):1768–1781. doi: 10.1158/0008-5472.CAN-22-3030

Figure 6. Structure of HPV sequences in Episomal and Integrated tumors.

Figure 6.

A. The structure of rearranged HPV-only reads in EP tumors is shown. The numbers represent the position of the HPV16 genome at the site of the breakpoint. Deletions are displayed between segments. Unless shown, all HPV sequences are arranged in the same orientation. B. Structure of HPV reads in putative type 2 tumors. Regions of human DNA are shown in light blue. C. The structure of HPV reads in tumor T429 is shown. HPV16 sequence breakpoints are shown joining chromosomes 4, 13, and X to HPV sequences. The position of a 63 bp duplication is shown. The top 2 diagrams represent independent sequence reads of 13,085 and 14,485 bp.