Table 2: Human NK Cell Differentiation Markers.
| HSC | MPP | CLP | NKP | Pre-NK Stage 2a | Pre-NK Stage 2b | iNK | mNK Stage 4a | mNK Stage 4b | mNK Stage 5 | mNK Stage 6 | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Lin | Lin (−) | Lin (−) | Lin (−) | Lin (−) | Lin (−) | Lin (−) | Lin (−) | Lin (−) | Lin (−) | Lin (−) | Lin (−) |
| CD34 | CD34 (+) | CD34 (low) | CD34 (+) | CD34 (+) | CD34 (+) | CD34 (+) | CD34 (+/−) | CD34 (−) | CD34 (−) | CD34 (−) | CD34 (−) |
| c-Kit | c-Kit (+) | c-Kit (low) | c-Kit (+) | c-Kit (+) | c-Kit (+) | c-Kit (+) | c-Kit (+) | c-Kit (+/low) | c-Kit (low/−) | c-Kit (low/−) | c-Kit (−) |
| CD150 | CD150 (+) | CD150 (−) | CD150 (−) | CD150 (−) | CD150 (−) | CD150 (−) | CD150 (−) | CD150 (−) | CD150 (−) | CD150 (−) | CD150 (−) |
| CD244 | CD244 (+) | CD244 (+) | CD244 (+) | CD244 (+) | CD244 (+) | CD244 (+) | CD244 (+) | CD244 (+) | CD244 (+) | CD244 (+) | |
| CD45RA | CD45RA (+) | CD45RA (+) | CD45RA (+) | CD45RA (+) | CD45RA (+) | CD45RA (+) | CD45RA (+/−) | CD45RA (+/−) | CD45RA (−) | CD45RA (−) | |
| CD127 | CD127 (+) | CD127 (+) | CD127 (+) | CD127 (+) | CD127 (+/−) | CD127 (−) | CD127 (−) | CD127 (−) | CD127 (−) | ||
| CD7 | CD7 (+) | CD7 (+) | CD7 (+) | CD7 (+) | CD7 (+) | CD7 (+) | CD7 (+) | CD7 (+) | CD7 (+) | ||
| CD10 | CD10 (+) | CD10 (+) | CD10 (+/−) | CD10 (−) | CD10 (−) | CD10 (−) | CD10 (−) | CD10 (−) | CD10 (−) | ||
| ILR1 | ILR1 (low) | ILR1 (−) | ILR1 (+) | ILR1 (+) | ILR1 (+/low) | ILR1 (low/−) | ILR1 (low/−) | ILR1 (low/−) | |||
| CD122 | CD122 (+) | CD122 (−) | CD122 (+) | CD122 (+) | CD122 (+) | CD122 (+) | CD122 (+) | CD122 (+) | |||
| HLA-DR | HLA-DR (+) | HLA-DR (+) | HLA-DR (+) | HLA-DR (−) | HLA-DR (−) | HLA-DR (−) | HLA-DR (−) | HLA-DR (−) | |||
| NKp46 | NKp46 (+/−) | NKp46 (+) | NKp46 (+) | NKp46 (+) | NKp46 (+) | ||||||
| NKp30 | NKp30 (+/−) | NKp30 (+) | NKp30 (+) | NKp30 (+) | NKp30 (+) | ||||||
| CD161 | CD161 (+/−) | CD161 (+) | CD161 (+) | CD161 (+) | CD161 (+) | ||||||
| NKG2D | NKG2D (+/−) | NKG2D (+) | NKG2D (+) | NKG2D (+) | NKG2D (+) | ||||||
| NKG2A | NKG2A (+) | NKG2A (+) | NKG2A (low/−) | NKG2A (low/−) | |||||||
| NKp80 | CD56 (++) | CD56 (++) | CD56 (low) | CD56 (low) | |||||||
| CD56 | NKp80 (+) | NKp80 (+) | NKp80 (+) | ||||||||
| CD16 | CD16 (+) | CD16 (+) | |||||||||
| KIR | KIR (+/−) | KIR (+) | |||||||||
| NKG2C | NKG2C (+) | NKG2C (+) | |||||||||
| CD57 | CD57 (+) |