Table 2.
Comparison of TAS2R2 activating compounds and their threshold concentrations with previously reported [3] TAS2Rs.
| TAS2R2 agonist | Threshold conc. | Other TAS2R | Threshold conc. |
|---|---|---|---|
|
| |||
| Chlorhexidine | 0.003 mM | TAS2R14 | 0.0001 mM |
|
| |||
| Chloroquine | 3 mM | TAS2R3 TAS2R10 TAS2R39 |
0.01 mM 10 mM 0.1 mM |
|
| |||
| 1,10-Phenanthroline | 1 mM | TAS2R5 | 0.1 mM |
|
| |||
| Phenylbutazone | 0.03 mM | - | - |
|
| |||
| Picrotoxinin | 1 mM | TAS2R1 TAS2R10 TAS2R14 TAS2R30 TAS2R46 |
1 mM 1 mM 0.003 mM 1 mM 0.01 mM |
|
| |||
| 6-propyl-thiouracil (PROP) | 3 mM | TAS2R38 | 0.00006 mM |
|
| |||
| Thiamine | 1 mM | TAS2R1 TAS2R39 |
1 mM 1 mM |
|
| |||
| Yohimbin | 0.3 mM | TAS2R1 TAS2R4 TAS2R10 TAS2R38 TAS2R46 |
0.3 mM 0.3 mM 0.3 mM 0.3 mM 0.3 mM |
|
|
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