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Disruption of lipid A biosynthesis by LpxH inhibitors. (A) A schematic illustration of the Raetz pathway of lipid A biosynthesis in E. coli. LpxH and its functional orthologs, LpxI and LpxG, are labeled in purple and green, respectively. (B) Chemical structures of the LpxH inhibitors: AZ1 (1), JH-LPH-33 (2), and JH-LPH-41 (3).
