Table 3.
Cox Regression for the associations of Visit 2 sMICA and sMICB levels (continuous variables per 1 relative fluorescent unit (RFU) decrease) with CRC risk in all participants and stratified by sex, race, or diabetes status; ARIC (1990–2015)
| N of incident CRC cases | Total person-years | HR (95% CI)a | ||
|---|---|---|---|---|
|
| ||||
| sMICA level | sMICB level | |||
|
| ||||
| All participants | ||||
|
| ||||
| 312 | 199,821 | 0.83 (0.66, 1.05) | 1.10 (0.87, 1.39) | |
|
| ||||
| Stratified by sex | ||||
|
| ||||
| Male | 161 | 83,933 | 0.68 (0.49, 0.96) | 0.98 (0.72, 1.33) |
| Female | 151 | 115,888 | 0.99 (0.71, 1.38) | 1.29 (0.90, 1.85) |
| P-interaction | 0.08 | 0.17 | ||
|
| ||||
| Stratified by race | ||||
|
| ||||
| White | 221 | 153,954 | 0.84 (0.64, 1.12) | 1.20 (0.91, 1.58) |
| Black | 91 | 45,867 | 0.80 (0.51, 1.25) | 0.87 (0.55, 1.36) |
| P-interaction | 0.97 | 0.37 | ||
|
| ||||
| Stratified by diabetes status | ||||
|
| ||||
| Yes | 59 | 25,983 | 0.79 (0.48, 1.31) | 0.83 (0.53, 1.31) |
| No | 253 | 173,838 | 0.83 (0.64, 1.08) | 1.20 (0.91, 1.58) |
| P-interaction | 0.86 | 0.18 | ||
a
Model was adjusted for age, sex, joint terms for race and study center (Black participants from Mississippi; Black participants from any of the other field centers; White participants from Maryland or North Carolina; and White participants from Minnesota), education, BMI, hormone replacement therapy (in women), aspirin use, smoking, pack-years of smoking, diabetes status, and eGFR.