Table 2:
Outcomes
| Univariate analysis | Multivariate analysis* | ||||||
|---|---|---|---|---|---|---|---|
| Estimates | 95 % CI | HR | 95 % CI | P-value | |||
| Overall Survival, 3 years | |||||||
| Young MUD | 68.5 | 55.6 | 78.4 | Ref | |||
| Young Haplo | 50.8 | 43.9 | 57.2 | 1.95 | 1.22 | 3.12 | 0.005 |
| Old Haplo | 42.2 | 36.5 | 47.9 | 2.36 | 1.50 | 3.71 | <0.001 |
| Relapse, 3 years | |||||||
| Young MUD | 36.4 | 24.8 | 48.2 | Ref | |||
| Young Haplo | 51.3 | 44.3 | 58.0 | 1.16 | 0.74 | 1.83 | 0.52 |
| Old Haplo | 41.1 | 35.8 | 46.4 | 0.95 | 0.61 | 1.48 | 0.82 |
| NRM, 3 years | |||||||
| Young MUD | 8.0 | 2.8 | 16.9 | Ref | |||
| Young Haplo | 11.0 | 7.5 | 15.2 | 3.72 | 1.39 | 9.93 | 0.009 |
| Old Haplo | 22.0 | 17.7 | 26.6 | 6.91 | 2.75 | 17.39 | <0.001 |
| Grade II-IV aGVHD, day 100 | |||||||
| Young MUD | 20.2 | 12.4 | 29.4 | Ref | |||
| Young Haplo | 25.8 | 21.0 | 30.9 | 1.67 | 0.98 | 2.83 | 0.06 |
| Old Haplo | 33.7 | 29.0 | 38.4 | 2.29 | 1.38 | 3.80 | 0.001 |
| Grade III-IV aGVHD, day 100 | |||||||
| Young MUD | 1.3 | 0.1 | 6.0 | Ref | |||
| Young Haplo | 7.8 | 5.1 | 11.3 | 2.06 | 0.81 | 5.22 | 0.13 |
| Old Haplo | 11.0 | 8.1 | 14.4 | 2.70 | 1.09 | 6.71 | 0.03 |
| Chronic GVHD, 2 years | |||||||
| Young MUD | 28.5 | 18.8 | 38.9 | Ref | |||
| Young Haplo | 23.1 | 18.3 | 28.3 | 0.89 | 0.56 | 1.45 | 0.66 |
| Old Haplo | 29.3 | 24.6 | 34.0 | 1.16 | 0.74 | 1.83 | 0.52 |
*
Full multivariate models with all adjusted covariates shown in supplemental table 5.
Abbreviations: CI, confidence interval; aGVHD, acute graft-versus-host disease; cGVHD chronic graft-versus-host disease; haplo, haploidentical; HR, hazard ratio; MUD, matched unrelated donor; NRM, non-relapse mortality; Ref: reference.