Table 2:
Odds ratios for cumulative respirable elemental carbon (REC) and risk of bladder cancer by TP53 tumor subtype from two-stage polytomous logistic regression in the New England Bladder Cancer Study.
| No TP53 mutation | TP53 mutation | ||||
|---|---|---|---|---|---|
| Cumulative REC ** (μg/m3-yrs) | Controls | Cases | Odds Ratio* (95% CI) |
Cases | Odds Ratio* (95% CI) |
| Case-case analysis | |||||
| Unexposed | - | 98 | Ref | 28 | Ref |
| 0 – 8.6 | - | 44 | Ref | 12 | 1.28 (0.55, 3.01) |
| >8.6 – 73.5 | - | 36 | Ref | 13 | 1.52 (0.65, 3.59) |
| >73.5 | - | 24 | Ref | 12 | 3.20 (1.28, 7.99) |
| p-trend | 0.015 | ||||
| Case-control analysis | |||||
| Unexposed | 639 | 98 | Ref | 28 | Ref |
| 0 – 8.6 | 255 | 44 | 1.06 (0.76, 1.48) | 12 | 1.36 (0.66, 2.78) |
| >8.6 – 73.5 | 211 | 36 | 0.86 (0.60, 1.23) | 13 | 1.30 (0.63, 2.69) |
| 013 | 139 | 24 | 0.89 (0.56, 1.40) | 12 | 2.84 (1.40, 5.74) |
| p-trend=0.603 | p-trend=0.003 | ||||
| p-heterogeneity = 0.013 | |||||
| Continuous REC (per 100 μg/m3-yrs) | 1244 | 202 | 1.05 (0.95, 1.15) | 65 | 1.11 (0.97, 1.28) |
*
Adjusted for age, race/ethnicity, sex, smoking status, and employment in a non-diesel related high-risk occupation.
**
Cut points for cumulative REC (tertiles) are based on TP53-mutated cases.
Note: counts do not add up to total due to exclusion of those possibly exposed to diesel from the reference group.