Table 1.
Association of murine models with the human breast cancer samples. * Distinction between Luminal A and Luminal B not provided by authors. Note that not all murine models currently available are shown in this table. Only the most representative subtypes of each model published in the literature was assigned here. MMTV = Mouse mammary tumor virus promoter / enhancer, WAP = Whey acidic protein promoter
| Murine Model | Human Breast Cancer Subtype | |||||
|---|---|---|---|---|---|---|
| Basal like / TNBC | Luminal A | Luminal B | HER2 Enriched | Normal Like | Claudin Low | |
| MMTV_PyMT | X | X | ||||
| MMTV-Neu | X | X | ||||
| MMTV-Myc (EMT) | X | |||||
| BRCA1+/-; p53+/-; IR | X | |||||
| MMTV-Cre BRCA1fl/fl p53+/- | X | X | ||||
| MMTV-Wnt1 | X | X | ||||
| Medroxyprogesterone DMBA induced | X | X | ||||
| C3(1)-Tag | X | X | ||||
| WAP-Myc | * | * | X | X | ||
| WAP-Int3 | * | * | ||||
| PI3KCA-H1047R | * | * | ||||
| Stat1 -/- | * | * | ||||
| WAP-T121 | X | X | ||||
| MMTV-LPA | X | X | ||||
| P53+/-; IR | X | X | ||||