Table 2.

Autocrine and paracrine actions of molecules in pancreatic endocrine cells

	Autocrine mediators of pancreatic β-cells		Paracrine mediators of pancreatic β-cells		Autocrine or Paracrine mediators of other endocrine cells
	Mediator	Target receptor	Mediator	Target receptor	Mediator	Target receptor
Hormones	Dopamine	D2R	Glucagon	GCGR	PP	NPY4R (in δ-cell), PPYR1 (in α-cell)
			SST-14	SSTR-5
	Serotonin	5HT1R	GLP-1	GLP1R
			Ghrelin	GHSR
Non-hormone mediators	GABA	GABA-A, GABA-B	Ach	M3R	Glutamate	Metabotropic R, AMPA/Kainate (Both in α-cell)
			Glutamate	Metabotropic receptor
	ATP	P2X/P2Y
	Glycine	GlyR

D2R dopamine receptor 2, 5HT1R 5-hydroxy tryptamine receptor 1, GABA Gamma amino butyric acid, GABA-A/B Gamma amino butyric acid receptor A/B, ATP Adenosine tri-phosphate, P2X/P2Y purinergic receptor 2X/2Y, GlyR Glycine receptor, GCGR glucagon receptor, SST-14 somatostatin-14, SSTR somatostatin receptor, GLP1 glucagon like peptide-1, GLP1R GLP-1 receptor, Ach acetylcholine, M3R muscarinic receptor, PP pancreatic polypeptide, NPY4R neuropeptide Y receptor subtype 4, PPYR1 pancreatic polypeptide receptor subtype 1, AMPA α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid