Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jun 3;13:9031. doi: 10.1038/s41598-023-36255-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Pseudotime analysis of oligodendrocytes across striatal development and with deletion of Foxp1. (A) Annotated UMAP of oligodendrocyte progenitor cells (OPCs), committed oligodendrocyte precursors (COPs), newly-formed oligodendrocytes (NFOL), myelin-forming oligodendrocytes (MFOL), mature oligodendrocytes (MOL) and progenitor clusters from the combined dataset. (B) Cells colored by PHATE pseudotime values. (C) Scaled expression of genes specific to each oligodendrocyte subtype. (D) Number of differentially expressed genes (DEGs) in OPCs from P9 dataset with deletion of Foxp1 from dSPNs, iSPNs, or both. Filled bars are upregulated DEGs (such as Mobp) and grey bars are downregulated DEGs. (E) Western blot of TUJ1 (housekeeping gene) and MOBP (oligodendrocyte marker) in striatal tissue in Foxp1^CTL, Foxp1^D1, Foxp1^D2, and Foxp1^DD mice and (F) quantification of MOBP levels relative to TUJ1 across genotypes (N = 5/genotype). Data is represented as mean ± SEM. P-values determined using a one-way ANOVA with Dunnett’s multiple comparison.