Classification of the COGs by functional categories. One-letter abbreviations for the functional categories: J, translation, including ribosome structure and biogenesis; L, replication, recombination and repair; K, transcription; O, molecular chaperones and related functions; M, cell wall structure and biogenesis and outer membrane; N, secretion, motility and chemotaxis; T, signal transduction; P, inorganic ion transport and metabolism; C, energy production and conversion; G, carbohydrate metabolism and transport; E, amino acid metabolism and transport; F, nucleotide metabolism and transport; H, coenzyme metabolism; I, lipid metabolism; D, cell division and chromosome partitioning; R, general functional prediction only; S, no functional prediction.