Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jun 3;14:3213. doi: 10.1038/s41467-023-38732-x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 3 — Both compound 5 (a) and dinaciclib (b) show a lower inhibitory potential of CDK2 with increasing concentrations of ATP, as quantified and compared in (c). One replicate was performed for the experiments with compound 5 while two technical replicates were performed for the experiments with dinaciclib and data points plotted in (b) represent the mean values. Source data for (a–c) are provided as a Source Data file. The DFG motif around D145 in the CDK2-compound 1 complex (d) adopts a different conformation in the CDK2-ATP complex (e, PDB ID 8FP5). f Superposition of the two complexes reveals that the backbone around the DFG motif (pink for CDK2-ATP, yellow for CDK2-compound 1) shifts by about 2 Å upon interaction with compound 1.