Table 1.

Enthalpic and entropic contributions of binding by each ligand and their respective affinity, as determined by ITC

Compound	n (binding stoichiometry)	∆H (kcal/mol)	T∆S (kcal/mol)	KD (nM)
1	0.747	−13	−5.4	5200
2	1.03	−9.4	−1.7	2300
3	1.27	−7.9	2.5	23
4	1.39	−5.5	4.8	31
5	1.52	−5.4	5.1	18