Table 2.

Correlation coefficients and p-values from one-sided Spearman correlation and partial Spearman correlation of regional semi-quantitative tau score and cortical thickness with age, sex, post-mortem interval and regional semi-quantitative TDP43 and α-synuclein scores as covariates. (A) Main regions with paired thickness and histopathology scores. (B) Exploratory regions in close proximity to the regions with available corresponding neuropathology score.

MRI region of interest	Corresponding Pathology region of interest	Correlation coefficient (p-value) of Spearman correlation between structure and local p-tau burden	Correlation coefficient (p-value) of partial Spearman correlation between structure and local p-tau burden
A
Entorhinal cortex	Entorhinal cortex	−0.58 (0.0005) *	−0.57 (0.0019) *
Subiculum	Cornu ammonis 1/subiculum	−0.35 (0.0263) *	−0.36 (0.0348) *
Primary visual cortex	Occipital gyrus	−0.27 (0.0622)	−0.33 (0.0413) *
Angular gyrus	Angular gyrus	−0.43 (0.0061) *	−0.31 (0.0519)
Superior temporal gyrus	Superior/middle temporal gyrus	−0.23 (0.1009)	−0.28 (0.071)
Middle frontal cortex	Middle frontal gyrus	−0.21 (0.1167)	−0.24 (0.1136)
Cornu ammonis 1	Cornu ammonis 1/subiculum	−0.09 (0.3224)	0.07 (0.3925)
B
Temporal pole	Amygdala	−0.45 (0.0039) *	−0.38 (0.0219) *
Insular gyrus	Middle frontal gyrus	−0.48 (0.0021) *	−0.36 (0.0318) *
Cingulate gyrus (Posterior)	Cingulate gyrus	−0.37 (0.0169) *	−0.34 (0.039) *
Superior parietal lobule	Angular gyrus	−0.36 (0.0207) *	−0.31 (0.0561)
Brodmann area 35	Entorhinal cortex	−0.24 (0.1029)	−0.22 (0.1488)
Ventrolateral part of inferior temporal gyrus	Entorhinal cortex	−0.15 (0.2106)	−0.07 (0.3616)
Cingulate gyrus (Anterior)	Cingulate gyrus	0.03 (0.5659)	−0.02 (0.4505)
Parahippocampal gyrus	Cornu ammonis 1/subiculum	−0.09 (0.3156)	−0.01 (0.4824)
Inferior frontal	Middle frontal gyrus	−0.10 (0.2917)	0.09 (0.3311)

^*Significant p-values.