Table 2.
Estimates of predicted TDP−43 and age effects on volume and flortaucipir uptake.
| Region | Age | TDP | ||||
|---|---|---|---|---|---|---|
| Volume | Tau (No PVC) | Tau (PVC) | Volume | Tau (No PVC) | Tau (PVC) | |
| Amygdala | −0.5% (−4%, 3%) | −5% (−8%, −2%) | −6% (−9%, −2%) | −3% (−11%, 5%) | 4% (−3%, 12%) | 6% (−2%, 14%) |
| Entorhinal cortex | −4% (−7%, 0.5%) | −5% (−9%, −2%) | −5% (−9%, −2%) | −13% (−21%, −4%) | 3% (−4%, 12%) | 6% (−3%, 15%) |
| Hippocampus | −4% (−7%, −1%) | −5% (−8%, −2%) | −5% (−8%, −1%) | −12% (−19%, −5%) | 1% (−7%, 9%) | 4% (−4%, 13%) |
| Temporal inf | 1% (−2%, 4%) | −11% (−16%, −7%) | −12% (−17%, −8%) | −4% (−12%, 4%) | −1% (−11%, 10%) | −1% (−11%, 11%) |
| Frontal mid | −4% (−10%, 2%) | −18% (−24%, −13%) | −19% (−25%, −14%) | −1% (−14%, 13%) | −6% (−18%, 7%) | −7% (−19%, 7%) |
| Dementia | ||||||
| Amygdala | −1% (−6%, 4%) | −5% (−9%, −1%) | −5% (−9%, −1%) | −4% (−14%, 6%) | 4% (−4%, 12%) | 5% (−4%, 15%) |
| Entorhinal cortex | −6% (−11%, −0.3%) | −5% (−9%, −1%) | −4% (−9%, −0.2%) | −15% (−24%, −4%) | 3% (−5%, 12%) | 5% (−4%, 15%) |
| Hippocampus | −6% (−11%, −2%) | −5% (−9%, −1%) | −4% (−9%, −0.2%) | −12% (−21%, −3%) | 1% (−7%, 10%) | 4% (−5%, 14%) |
| Temporal inf | 2% (−3%, 6%) | −11% (−16%, −5%) | −12% (−18%, −6%) | −8% (−17%, 2%) | 2% (−9%, 15%) | 3% (−9%, 17%) |
| Frontal mid | −2% (−10%, 6%) | −22% (−29%, −14%) | −23% (−31%, −15%) | −3% (−20%, 15%) | −1% (−16%, 15%) | −1% (−16%, 16%) |
Data are shown as estimates (95% confidence intervals). Results of multivariate regression model are shown. The upper rows show results from the primary analyses with all participants. The lower rows show results from the sensitivity analyses with subgroup of participants with dementia. Abbreviations: frontal mid = middle frontal cortex; temporal inf = inferior temporal cortex