Table 7.
Results of Autologous Hematopoietic Stem Cell Transplant in Pediatric Relapsed/Refractory Hodgkin Lymphoma
| Author (Reference) | N. Patients | Median Age (Years) (Range) | Years | Disease Evaluation Before HSCT | Outcome (Years) |
|---|---|---|---|---|---|
| Williams (1993)105 | 81 | 16.9 (5.2–32.6) | < 1992 | NR | PFS 39% (3) |
| Brice (1997)99 | 280 | 30 (5–59) | 1982–1993 | NR | OS 66%; PFS 60% (4) |
| Baker (1999)106 | 53 | < 21 | 1984–1996 | NR | OS 43%; EFS 31% (5) |
| Verdeguer (2000)109 | 20 | 10.5 (5–18) | 1986–1997 | NR | OS 95%; EFS 62% (5) |
| Stoneham (2004)107 | 51 | 12 (3–16) | 1982–2000 | RX/CT | 34 patients alive (median FU 4.5 years) |
| Frankovich (2001)108 | 34 | 17 (7–21) | 1989–1998 | RX/CT | OS 79%; DFS 67% (5) |
| Lieskovsky (2004)110 | 41 | 18 (7–20) | 1989–2001 | RX/CT | OS 68%; EFS 53% (5) |
| Claviez (2008)111 | 74 | 14 (84–18) | NR | NR | OS 59%; PFS 50% (5) |
| Schellong (2005)113 | 53 | 14.7 (4.3–24.5) | 1986–2003 | RX/TC | OS 75%; EFS 57% (10) |
| Metzger (2010)118 | 50 | 16.1 (14.9–22) | 1990–2006 | CT/FDG-PET | OS 58% (5) |
| Gorde-Crosjean (2011)119 | 50 | 15 (4–20) | 1990–2006 | CT/FDG-PET | OS 66%; DFS 64% (median FU 40 mos) |
| Harris (2011)73 | 28 | < 21 | 2000–2010 | NR | OS 63%; EFS 65% (3) |
| Sumaili (2014)117 | 29 | 9.8 (3.6–16.7) | 1995–2012 | NR | OS 61.9%; EFS 60.4% (5) |
| Garfin (2015)112 | 89 | 17.8 (8–21) | 1989–2012 | CT/FDG-PET | OS 71%; EFS 65% (5) |
| Satwani (2015)114 | 606 | 23 (3–29) | 1995–2010 | NR | OS 58%; PFS 47% (5) |
| Hazar (2015)79 | 66 | 15 (7–20) | 1993–2013 | NR | OS 63%; EFS 54% (median FU 43 mos) |
| Giulino-Roth (2018)115 | 36 | 17.7 (9.7–21) | 1989–2013 | CT/FDG-PET | OS 74.1%; EFS 67.1% (10) |
Abbreviations: CT, computed tomography; DFS, disease free survival; EFS, event free survival; FDG/PET, fluorodeoxyglucose positron emission computed tomography; FU, follow-up; HSCT, hematopoietic stem cell transplant; mos, months; NR, not reported; OS, overall survival; PFS, progression free survival; RX, radiography.