| Adverse event (AE) profiles for antiseizure medications differ between modes of action and between single substances with the same molecular target. |
| Perampanel is an AMPA receptor antagonist that is associated with an unfavorable AE profile. |
| Topiramate, valproate, and zonisamide therapy are associated with an unfavorable AE profile. |
| Brivaracetam produces fewer psychobehavioral AEs than levetiracetam. |
| Voltage-gated sodium channel( modulators such as dibenzazepines, lamotrigine, and lacosamide have favorable AE profiles. |
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