Table 7.
Antitubercular Activity of Compound 62 Against Susceptible, MDR, and XDR Strains of Mtb
| Strain/phenotype | Mtb MIC (μg/mL) | ||||
|---|---|---|---|---|---|
| V4207/ DSa |
V2475/ MDRb |
KZN494/ MDRb |
R506/ XDRc |
TF274/ XDRc |
|
| 62 | 0.0039 | 0.0625 | 0.0156–0.0313 | 0.0313 | 0.0039 |
| Isoniazid | 0.04 | 16 | 16 | 8 | 8 |
| Rifampin | 0.0625 | 4 | 128 | >128 | >128 |
| Levofloxacin | 0.125 | NT | NT | 2 | 1 |
| Ofloxacin | 0.5 | 0.5 | 0.5 | 4 | 8 |
| Kanamycin | 2 | 2 | 2 | >128 | >128 |
a
Drug susceptible strain of Mtb.
b
Multidrug resistant strain of Mtb.
c
Extensively drug resistant strain of Mtb.
d
The lowest concentration of the drug leads to at least a 90% reduction of bacterial growth signal by microplate Alamar Blue assay (MABA); reported MIC values are an average of three individual measurements.