Table 2.
Participant Characteristics by Cohort
| Analysis of IOP | Analysis of OCT Parameters | Analysis of Glaucoma Status | |
|---|---|---|---|
|
| |||
| Sample size | 81 324 | 36 143 | 84 655 |
| Age (years), mean (SD) | 56.6 (8.1) | 56.3 (8.1) | 56.6 (8.1) |
| Sex, n (%) | |||
| Women | 43 214 (53.1) | 18 835 (52.1) | 44 970 (53.1) |
| Men | 38 110 (46.9) | 17 308 (47.9) | 39 685 (46.9) |
| Ethnicity, n (%) | |||
| White | 73 548 (90.4) | 33 081 (91.5) | 76 677 (90.6) |
| Black | 2642 (3.3) | 1071 (3.0) | 2720 (3.2) |
| Other | 5134 (6.3) | 1991 (5.5) | 5258 (6.2) |
| Townsend deprivation index, mean (SD) | −1.1 (2.9) | −1.1 (2.9) | −1.1 (2.9) |
| Body mass index (kg/m2), mean (SD) | 27.3 (4.7) | 27.2 (4.7) | 27.3 (4.7) |
| Height (cm), mean (SD) | 168.9 (9.3) | 169.3 (9.2) | 168.9 (9.3) |
| Systolic blood pressure (mmHg), mean (SD) | 137.0 (18.3) | 136.8 (18.3) | 137.1 (18.3) |
| Spherical equivalent (D), mean (SD) | −0.4 (2.7) | 0.0 (2.0) | −0.4 (2.7) |
| Diabetes, n (%) | 4411 (5.4) | 1782 (4.9) | 4616 (5.5) |
| Smoking status, n (%) | |||
| Never | 46 741 (57.5) | 20 542 (56.8) | 48 652 (57.5) |
| Previous | 29 248 (36.0) | 13 280 (36.7) | 30 458 (36.0) |
| Current | 5335 (6.6) | 2321 (6.4) | 5545 (6.6) |
| Smoking intensity (cigarettes/day), mean (SD) | |||
| Current smokers | 14.5 (8.2) | 13.8 (7.8) | 14.5 (8.3) |
| Physical activity (MET-minutes/week), mean (SD) | 2669 (2 678) | 2692 (2 706) | 2666 (2 676) |
| Intraocular pressure (mmHg), mean (SD) | 16.1 (3.4) | — | — |
| mRNFL thickness (mm), mean (SD) | — | 28.9 (3.8) | — |
| mGCIPL thickness (mm), mean (SD) | — | 75.2 (5.2) | — |
| Glaucoma, n (%) | — | — | 1 493 (1.8) |
| Alcohol consumption frequency, n (%) | |||
| Never | 3 906 (4.8) | 1 536 (4.3) | 4 077 (4.8) |
| Infrequent | 9 700 (11.9) | 4 184 (11.6) | 10 097 (11.9) |
| Regular | 64 803 (79.7) | 29 136 (80.6) | 67 421 (79.6) |
| Former | 2915 (3.6) | 1287 (3.6) | 3060 (3.6) |
| Alcohol intake quantity (g/week), median (IQR) | |||
| Infrequent | 2.8 (0.0–7.9) | 2.8 (0.0–8.1) | 2.8 (0.0–7.9) |
| Regular | 91.3 (43.3–170.9) | 92.8 (44.6–173.5) | 91.8 (43.8–171.6) |
| Glaucoma MTAG, mean (SD)1 | −0.04 (1.04) | −0.05 (1.04) | −0.04 (1.04) |
Note: n = 50 455 (IOP), n = 22 697 (OCT), n = 52 481 (glaucoma).
D — diopter. IOP — intraocular pressure; IQR — interquartile range; MET — metabolic equivalent of task; mGCIPL — macular ganglion cell—inner plexiform layer; mRNFL — macular retinal nerve fiber layer; MTAG — multitrait analysis of GWAS (genome-wide association study); SD — standard deviation.