Table 2.

Descriptive statistics of pre-vaccination anti-PEG-IgG and IgM levels and distributions in humans.

	Anti-PEG IgG [ng(eq)/mL]				Anti-PEG IgM [ng(eq)/mL]
	All	Male	Female	F/M#	All	Male	Female	F/M
N of subjects	116&	40	76	1.90	118&	41	77	1.88
N below detection limit#	2	1	1	1.00	1	0	1	NA
25 % Percentile	10,584	8,281	14,929	1.80	38	23	46	2.00
Median	30,681	23,108	37,198	1.61	105	60	132*	2.20
Log-normal mean (μ)	35,893	30,903	38,815	1.26	109	73	136**	1.86
SD of log-normal mean (σ)	4	4	4	1.00	4	4	4	1.00
Lower 99 % Cl of μ	25,119	16,106	25,003	1.55	78	42	89	2.12
Upper 99 % Cl of μ*	51,404	59,293	60,395	1.02	153	129	207	1.60
75 % Percentile	87,165	76,176	88,111	1.16	297	209	397	1.90
Maximum	1,362,175	1,048,553	1,362,175	1.30	2,796	1,829	2,796	1.53
Maximum/Median	44	45	37	0.81	27	30	21	0.69
95 % Percentile	674,368	665,283	612,709	0.99	1,344	706	1,657	2.35
95 % Percentile/Median	22.0	28,8	16,5	0.57	12.8	11.8	12.6	10.8

N, number; CI, confidence interval; ^#, F/M, female/male ratios; ^&The difference in male and female number of subjects is due to 2 erroneous IgG determinations; ^#, Samples below the detection limit were excluded from normalized data analysis; *, significant difference between female and male at p = 0,044 (Mann Whitney test); ** p = 0,023 (unpaired t test on logarithmic transformed data after their normal distribution was checked by the Shapiro-Wilk test).