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. 2023 Jun 5;34:101136. doi: 10.1016/j.scp.2023.101136

Table 2.

Comparison of the methods of synthesis of imidazolines based on reactions of benzaldehyde and ethylenediamine.

Entry Reagent Solvent Temp. (oC) Time (min) Yields (%) Ref.
1 H2O2, NaI, MgSO4 t-BuOH 80 30 96 Bai et al., (2011)
2 K4Fe(CN)6 H2O r.t 30 85 Shaikh et al. (2012)
3 a HPW, b TBAB H2O 80 120 93 Liu et al. (2019)
4 c NBS dry TBME or CH2Cl2 0 30 99 Fujioka et al. (2007)
5 I2/KI/K2CO3 H2O 90 30 90 Gogoi and Konwar, 2006
6 I2,K2CO3 t-BuOH 70 180 100 Ishihara and Togo (2007a)
7 d CAN Dry-CH2Cl2 Reflux 15 90 Kumar and Joshi (2007)
8 NBS H2O 65–70 12 99 Sant’ Anna et al., 2009
9 NBSac CH2Cl2 r.t 20 96 This work
a

Tungstophosphoric acid.

b

Tetrabutylammonium bromide.

c

N-bromosuccinimide.

d

Ceric ammonium nitrate.