TABLE 3.
The molecular and cellular mechanisms underlying the cardioprotective effect of Curcumin treatment in myocardial ischemia/reperfusion injury.
| Author | Published year | Proposed mechanisms |
|---|---|---|
| Ansari et al., | 2007 | Enhance the antioxidant capability |
| Boarescu et al., | 2019 | Enhance antioxidative and anti-inflammatory effects |
| Boarescu et al., | 2019 | Limit the increase in inflammatory cytokine levels and MMP2/9 expression |
| Chen et al., | 2018 | Increase HO-1 activity and expression |
| Cheng et al., | 2005 | Reduce lipid peroxide and increase production of endogenous antioxidative substances |
| Ding et al., | 2020 | Reduce myocardial enzyme release and enhance antioxidant capacity |
| Duan et al., | 2012 | Activate of the JAK2/STAT3 signaling pathway |
| Geng et al., | 2016 | Upregulate miR-7a/b expression and downregulate of SP1 expression |
| Gu et al., | 2016 | Inhibit TLR4/NF-kappaB signaling pathway |
| Izem-Meziane et al., | 2012 | Prevent mitochondrial damaging and mitochondrial permeability transition pore (mPTP) opening |
| Javanmard et al., | 2019 | NA |
| Jeong et al., | 2012 | Activate RISK/GSK-3β and inhibit p38 and JNK. |
| Jo et al., | 2020 | NA |
| Kim et al., | 2012 | Selective inhibit of TLR2 |
| Li et al., | 2019 | Immunomodulatory effect |
| Li et al., | 2020 | NA |
| Liu et al., | 2017 | Stimulate JAK2/STAT3 signal pathway, decrease oxidative damage, and inhibit myocardium apoptosis |
| Manikandan et al., | 2004 | Inhibit xanthine dehydrogenase/xanthine oxidase (XD/XO) conversion and resultant superoxide anion production |
| Nirmala et al., | 1996 | Increase activity of cathepsin D in mitochondrial, lysosomal, and microsomal fractions |
| Rahnavard et al., | 2019 | Reduce oxidative status by reducing SOD and MDA contents |
| Su et al., | 2014 | NA |
| Sun et al., | 2016 | Suppresses ROS-mediating mitochondrial apoptosis |
| Tanwar et al., | 2010 | Stabilize cytoskeleton structure and increase Hsp27 expression |
| Wang et al., | 2013 | Activate Notch signaling pathway |
| Wang et al., | 2014 | Downregulate expression of EGR-1 and inhibit inflammation-mediated processes |
| Wang et al., | 2018 | Activate SIRT3 |
| Wu et al., | 2011 | NA |
| Wu et al., | 2021 | Downregulate the expression of Bax and upregulate the expression of Bcl2, p-mTOR and p-AKT |
| Yan et al., | 2021 | Suppress inflammation by modulating macrophage polarization via the AMPK pathway |
| Yang et al., | 2012 | Activate anti-apoptotic signaling pathway |
| Yang et al., | 2013 | Activate of SIRT1 signaling and the alleviate of mitochondrial oxidative damage |
| Yao et al., | 2014 | Anti-oxidative injury and upregulate activity and expression of HO-1 protein |
| Zhao et al., | 2010 | NA |
| Zhao et al., | 2022 | Inhibit of macrophage-fibroblast crosstalk and activate of IL18-TGFβ1-p-SMAD2/3 signaling pathway in cardiac fibroblasts |