TABLE 4.
Subgroup analysis of pooled estimates of infarct size.
| Subgroup | No. of studies | SMD | 95% CI | P value between subgroups | heterogeneity within subgroups | |
|---|---|---|---|---|---|---|
| I2(%) | P value | |||||
| Species | 0.81 | |||||
| SD rats | 13 | -5.34 | -6.60, -4.08 | 72 | < 0.01 | |
| Wistar rats | 3 | -6.98 | -11.96, -1.99 | 81 | < 0.01 | |
| C57BL/6 mice | 6 | -5.73 | -9.14, -2.32 | 96 | < 0.01 | |
| Model | 0.08 | |||||
| I/R | 15 | -5.48 | -6.77, -4.19 | 74 | < 0.01 | |
| MI | 5 | -4.90 | -8.46, -1.33 | 96 | < 0.01 | |
| ISO | 2 | -9.48 | -12.83; -6.13 | 0 | 0.50 | |
| Dose | <0.01 | |||||
| Perfused | 6 | -6.50 | -7.86, -5.14 | 26 | 0.24 | |
| ≤50mg/kg | 6 | -5.32 | -7.49, -3.14 | 77 | <0.01 | |
| 50-100mg/kg | 8 | -5.94 | -8.84, -3.04 | 95 | <0.01 | |
| >100mg/kg | 2 | -3.13 | -4.50, -1.75 | 90 | <0.01 | |
| Drug Delivery | 0.26 | |||||
| Perfused | 6 | -6.50 | -7.86, -5.14 | 26 | 0.24 | |
| Intraperitoneal | 4 | -5.30 | -9.33, -1.28 | 93 | < 0.01 | |
| Oral | 11 | -5.46 | -7.51, -3.42 | 90 | < 0.01 | |
| Intravenous | 1 | -4.29 | -6.00, -2.57 | / | / | |
| Duration | 0.37 | |||||
| <1day | 11 | -5.96 | -7.40, -4.52 | 74 | < 0.01 | |
| 1day-1week | 3 | -4.02 | -6.35, -1.69 | 68 | 0.05 | |
| >1week | 8 | -5.84 | -8.73, -2.95 | 94 | < 0.01 | |
Note: SMD, standardized mean difference; SD rats, Sprague-Dawley rats; I/R, ischemia/reperfusion; MI, myocardial infarction; ISO, isoproterenol.