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. 2023 May 22;11:1190637. doi: 10.3389/fbioe.2023.1190637

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Copyright © 2023 He, Jiang, Zhang, Li, Hu, Hua, Cai, Mo and Peng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Establishment of a biobank of mCRC PDOs. (A) Flow diagram of the study, including the establishment of mCRC organoid lines, as well as the histological characterization, drug screen on organoids. (B) Time course culture of mCRC organoids with different morphologies (CRC-PDO5, irregular solid/compact structures; CRC-PDO30, thin-walled cystic structures). (C) Histopathological features of primary tumors and PDOs. H&E comparison of four CRC organoids (LM-P2, OM-P6, CRC-P10, and CRC-P14) with the corresponding tumor from which they were derived (4 mCRC patients). Representative images of these CRC organoids in bright-field were displayed (top). Black scale bar, 100 μm. Red scale bar, 50 μm. PDOs, patient-derived organoids; mCRC, metastatic colorectal cancer; LM, liver metastasis; OM, ovarian metastasis.