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. 2023 May 22;11:1190637. doi: 10.3389/fbioe.2023.1190637

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Copyright © 2023 He, Jiang, Zhang, Li, Hu, Hua, Cai, Mo and Peng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Drug responses of metastatic colorectal cancer organoid lines. Violin plot showing the distribution of the standardized IC50 values of the drugs, (A) 5FU, (B) CPT11 and (C) Oxaliplatin, in 30 mCRC organoids; Violin plot showing the standardized IC50 values of 15 mCRC organoids for (D) FOLFOX, (E) FOLFIRI, and (F) FOLFIRINOX chemosensitivity. Ex vivo chemosensitivity of four representative mCRC organoids, (G) OM-PDO6, (H) CRC-PDO29, (I) CRC-PDO15, and (J) CRC-PDO31, to 5-FU, CPT11, Oxaliplatin, and FOLFIRINOX presented in the form of standardized IC50s.