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. 2023 May 22;14:1166814. doi: 10.3389/fphar.2023.1166814

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Copyright © 2023 Ge, Wang, Yao, Wang, Zheng, Luo, Chen, Wang, Wang, Wang, Lin, Shi and Yao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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STC3141 improves lung injury scores for LPS-induced ALI in rats. Representative histology of the right upper lobe in the different groups (A) in sham group (B) LPS group (C) LPS + L group (D) LPS + M group (E) LPS + H group (F) LPS + D group. (G) Lung injury score. All images are taken after HE staining and amplified 100X. Data are presented as means ± SEM, n = 7. ***p < 0.001 versus the sham group; ##p < 0.01, and ###p < 0.001 versus the LPS group. Note that the artifactual expansion of the peribronchial tissue (asterisk), which commonly results from tissue processing, does not represent edema. Lung inflammation, with neutrophil-based inflammatory cells (alveolar cavity, blood vessel, alveolar wall), alveolar wall thickening, bleeding in the alveoli (arrows).