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. 2023 Apr 3;24(6):e56019. doi: 10.15252/embr.202256019

Figure EV5. The historical contingency model for the fates of spontaneous deleterious sef1 loss‐of‐function mutations.

Figure EV5

In this hypothetical model, the upper panel shows that the subsequent formation of the sef1 loss‐of‐function mutations under mild (28°C) or harsh (heat stress) selective conditions are preserved by the presence of pre‐existing primary beneficial mutations (e.g., ira1 or azf1) in the founder population (e.g., the wild‐type population). The primary mutations alleviate the deleterious effects of sef1 mutations. The loss‐of‐function sef1 genotypes are unable to be preserved in the population without the primary mutations (bottom panel). However, whether the secondarily formed sef1 subpopulation can compete with the primary population and then expand is not guaranteed, possibly depending on their pleiotropies and the selections by changing environments in the future.

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