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. 2023 May 22;14:1172960. doi: 10.3389/fneur.2023.1172960

Table 2.

FCR axon excitability parameters in the paretic (P), non-paretic (NP), and control (C) limbs.

Excitability parameter Paretic
n = 16
Non-paretic
n = 16
Control
n = 19
P vs. NP
p-value
P vs. C
p-value
NP vs. C
p-value
Stimulus–response
CMAP peak (mV) 7.6 ± 0.7 9.4 ± 0.4 9.8 ± 0.3 0.01 0.006 0.4
Latency (ms) 5.0 ± 0.1 4.8 ± 0.1 4.7 ± 0.1 0.1 0.02 0.3
Stimulus (mA) for 50%max 7.9 ± 0.7 7.4 ± 0.6 5.9 ± 0.4 0.4 0.05 0.08
Stimulus–response slope 3.9 ± 0.2 3.4 ± 0.2 3.5 ± 0.1 0.01 0.1 0.8
Stimulus width-charge
SDTC (ms) 0.456 ± 0.015 0.418 ± 0.016 0.487 ± 0.018 0.05 0.2 0.009
Rheobase (mA) 5.1 ± 0.5 4.9 ± 0.4 3.8 ± 0.3 0.6 0.06 0.07
Recovery cycle
RRP (ms) 3.77 ± 0.21 3.23 ± 0.15 3.73 ± 0.16 0.0002 0.9 0.02
Refractoriness at 2.5 ms (%) 28.5 ± 5.4 17.6 ± 3.5 33.1 ± 3.6 0.0008 0.5 0.004
Superexcitability (%) −10.5 ± 1.9 −12.9 ± 1.9 −8.2 ± 1.3 0.05 0.3 0.03
Subexcitability (%) 11.9 ± 1.8 10.2 ± 1.4 13.1 ± 1.6 0.4 0.6 0.2
TE to ±40% currents
TEd (10–20 ms) (%) 65.6 ± 1.7 65.5 ± 1.7 61.9 ± 1.0 0.9 0.06 0.07
TEd (40–60 ms) (%) 54.7 ± 2.2 55.7 ± 2.0 49.7 ± 1.0 0.5 0.03 0.007
TEd (90–100 ms) (%) 50.4 ± 1.8 51.0 ± 1.6 44.9 ± 1.1 0.7 0.02 0.007
TEd (undershoot) (%) −11.8 ± 0.7 −11.0 ± 1.0 −12.9 ± 0.6 0.6 0.3 0.1
S2 accommodation (%) 15.9 ± 0.6 16.0 ± 1.0 17.0 ± 0.7 0.8 0.2 0.4
Accommodation ½-time (ms) 41.5 ± 1.3 41.7 ± 0.7 40.2 ± 0.7 0.4 0.4 0.1
TEh (10–20 ms) (%) −72.9 ± 1.9 −72.2 ± 1.4 −69.4 ± 1.1 0.6 0.1 0.1
TEh (20–40 ms) (%) −93.7 ± 3.4 −91.9 ± 2.2 −85.8 ± 1.7 0.5 0.03 0.03
TEh (90–100 ms) (%) −138.7 ± 7.1 −136.2 ± 5.5 −120.1 ± 3.5 0.6 0.01 0.01
TEh (overshoot) (%) 3.7 ± 0.8 3.7 ± 0.9 5.9 ± 0.6 0.5 0.04 0.07
I/V relationship
Resting I/V slope 0.53 ± 0.03 0.52 ± 0.02 0.60 ± 0.01 0.6 0.02 0.009
Minimum I/V slope 0.17 ± 0.00 0.17 ± 0.00 0.18 ± 0.00 0.9 0.01 0.03
Hyperpolarizing I/V slope 0.27 ± 0.02 0.30 ± 0.02 0.23 ± 0.01 0.1 0.1 0.005