Table 2.
FCR axon excitability parameters in the paretic (P), non-paretic (NP), and control (C) limbs.
Excitability parameter | Paretic n = 16 |
Non-paretic n = 16 |
Control n = 19 |
P vs. NP p-value |
P vs. C p-value |
NP vs. C p-value |
---|---|---|---|---|---|---|
Stimulus–response | ||||||
CMAP peak (mV) | 7.6 ± 0.7 | 9.4 ± 0.4 | 9.8 ± 0.3 | 0.01 | 0.006 | 0.4 |
Latency (ms) | 5.0 ± 0.1 | 4.8 ± 0.1 | 4.7 ± 0.1 | 0.1 | 0.02 | 0.3 |
Stimulus (mA) for 50%max | 7.9 ± 0.7 | 7.4 ± 0.6 | 5.9 ± 0.4 | 0.4 | 0.05 | 0.08 |
Stimulus–response slope | 3.9 ± 0.2 | 3.4 ± 0.2 | 3.5 ± 0.1 | 0.01 | 0.1 | 0.8 |
Stimulus width-charge | ||||||
SDTC (ms) | 0.456 ± 0.015 | 0.418 ± 0.016 | 0.487 ± 0.018 | 0.05 | 0.2 | 0.009 |
Rheobase (mA) | 5.1 ± 0.5 | 4.9 ± 0.4 | 3.8 ± 0.3 | 0.6 | 0.06 | 0.07 |
Recovery cycle | ||||||
RRP (ms) | 3.77 ± 0.21 | 3.23 ± 0.15 | 3.73 ± 0.16 | 0.0002 | 0.9 | 0.02 |
Refractoriness at 2.5 ms (%) | 28.5 ± 5.4 | 17.6 ± 3.5 | 33.1 ± 3.6 | 0.0008 | 0.5 | 0.004 |
Superexcitability (%) | −10.5 ± 1.9 | −12.9 ± 1.9 | −8.2 ± 1.3 | 0.05 | 0.3 | 0.03 |
Subexcitability (%) | 11.9 ± 1.8 | 10.2 ± 1.4 | 13.1 ± 1.6 | 0.4 | 0.6 | 0.2 |
TE to ±40% currents | ||||||
TEd (10–20 ms) (%) | 65.6 ± 1.7 | 65.5 ± 1.7 | 61.9 ± 1.0 | 0.9 | 0.06 | 0.07 |
TEd (40–60 ms) (%) | 54.7 ± 2.2 | 55.7 ± 2.0 | 49.7 ± 1.0 | 0.5 | 0.03 | 0.007 |
TEd (90–100 ms) (%) | 50.4 ± 1.8 | 51.0 ± 1.6 | 44.9 ± 1.1 | 0.7 | 0.02 | 0.007 |
TEd (undershoot) (%) | −11.8 ± 0.7 | −11.0 ± 1.0 | −12.9 ± 0.6 | 0.6 | 0.3 | 0.1 |
S2 accommodation (%) | 15.9 ± 0.6 | 16.0 ± 1.0 | 17.0 ± 0.7 | 0.8 | 0.2 | 0.4 |
Accommodation ½-time (ms) | 41.5 ± 1.3 | 41.7 ± 0.7 | 40.2 ± 0.7 | 0.4 | 0.4 | 0.1 |
TEh (10–20 ms) (%) | −72.9 ± 1.9 | −72.2 ± 1.4 | −69.4 ± 1.1 | 0.6 | 0.1 | 0.1 |
TEh (20–40 ms) (%) | −93.7 ± 3.4 | −91.9 ± 2.2 | −85.8 ± 1.7 | 0.5 | 0.03 | 0.03 |
TEh (90–100 ms) (%) | −138.7 ± 7.1 | −136.2 ± 5.5 | −120.1 ± 3.5 | 0.6 | 0.01 | 0.01 |
TEh (overshoot) (%) | 3.7 ± 0.8 | 3.7 ± 0.9 | 5.9 ± 0.6 | 0.5 | 0.04 | 0.07 |
I/V relationship | ||||||
Resting I/V slope | 0.53 ± 0.03 | 0.52 ± 0.02 | 0.60 ± 0.01 | 0.6 | 0.02 | 0.009 |
Minimum I/V slope | 0.17 ± 0.00 | 0.17 ± 0.00 | 0.18 ± 0.00 | 0.9 | 0.01 | 0.03 |
Hyperpolarizing I/V slope | 0.27 ± 0.02 | 0.30 ± 0.02 | 0.23 ± 0.01 | 0.1 | 0.1 | 0.005 |