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. 2023 May 26;5(3):e220180. doi: 10.1148/rycan.220180

Figure 1:

Characterization of spectrally distinct Aurelia-1 and Aurelia-2 gold nanorods (GNRs). (A) Dynamic light scattering–based distribution of Aurelia-1 (larger peak [LP], 101.4 ± 1.53 [SD]; polydispersity index [PDI], 0.82 ± 0.004) (smaller peak [SP], 3.06 ± 0.02; PDI, 0.82 ± 0.004). (B) Dynamic light scattering–based distribution of Aurelia-2 (LP, 68.76 ± 1.04; PDI, 0.82 ± 0.004) (SP, 1.06 ± 0.03; PDI, 0.82 ± 0.004). (C) Multispectral optoacoustic tomography (MSOT)–based detection of Aurelia-1 (blue) and Aurelia-2 (red) GNRs inside a tissue-mimicking phantom. (D, E) MSOT identification of the near-infrared spectral shape of Aurelia-1 (absorption peak at 780 nm) and Aurelia-2 (absorption peak at 720 nm). (F) MSOT detection of predefined blue (Aurelia-1) and red (Aurelia-2) color from the mixture of 1 mg of both GNRs after spectral unmixing. (G, H) Transmission electron microscopy image findings determined GNR size and total Aurelia-1 and Aurelia-2 size. Aurelia-1 and Aurelia-2 GNR sizes were as follows: Aurelia-1 length: 44.9 nm ± 2.01, width: 35.75 nm ± 1.20; Aurelia-2 length: 21.21 nm ± 2.12, width: 9.13 nm ± 0.25. The total particle sizes, including silica and chitosan, of Aurelia-1 and Aurelia-2 were as follows: Aurelia-1 length: 50.5 nm ± 3.06, width: 38.92 nm ± 0.87; Aurelia-2 length: 23.52 nm ± 2.09, width: 10.23 nm ± 0.43. a.u. = arbitrary units.

Characterization of spectrally distinct Aurelia-1 and Aurelia-2 gold nanorods (GNRs). (A) Dynamic light scattering–based distribution of Aurelia-1 (larger peak [LP], 101.4 ± 1.53 [SD]; polydispersity index [PDI], 0.82 ± 0.004) (smaller peak [SP], 3.06 ± 0.02; PDI, 0.82 ± 0.004). (B) Dynamic light scattering–based distribution of Aurelia-2 (LP, 68.76 ± 1.04; PDI, 0.82 ± 0.004) (SP, 1.06 ± 0.03; PDI, 0.82 ± 0.004). (C) Multispectral optoacoustic tomography (MSOT)–based detection of Aurelia-1 (blue) and Aurelia-2 (red) GNRs inside a tissue-mimicking phantom. (D, E) MSOT identification of the near-infrared spectral shape of Aurelia-1 (absorption peak at 780 nm) and Aurelia-2 (absorption peak at 720 nm). (F) MSOT detection of predefined blue (Aurelia-1) and red (Aurelia-2) color from the mixture of 1 mg of both GNRs after spectral unmixing. (G, H) Transmission electron microscopy image findings determined GNR size and total Aurelia-1 and Aurelia-2 size. Aurelia-1 and Aurelia-2 GNR sizes were as follows: Aurelia-1 length: 44.9 nm ± 2.01, width: 35.75 nm ± 1.20; Aurelia-2 length: 21.21 nm ± 2.12, width: 9.13 nm ± 0.25. The total particle sizes, including silica and chitosan, of Aurelia-1 and Aurelia-2 were as follows: Aurelia-1 length: 50.5 nm ± 3.06, width: 38.92 nm ± 0.87; Aurelia-2 length: 23.52 nm ± 2.09, width: 10.23 nm ± 0.43. a.u. = arbitrary units.