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. 2023 May 26;5(3):e220180. doi: 10.1148/rycan.220180

Figure 5:

(A) Graph depicts a linear curve with various gold (Au) concentrations, translating into gold per gram of tissue, that confirms the presence of gold in mouse and human tissues. The 1000 µg/mL stock solution of platinum diluted to 0.4 µg/mL with 2% (w/v) nitric acid + 0.5% hydrochloric acid (w/v) is used as an internal standard. (B) Inductively coupled plasma mass spectrometry (ICP-MS) instrument parameters used in the gold analysis. (C) Comparison of the actual versus calculated gold concentrations observed during the ICP-MS analysis. (D) DY36T2Q breast tumors from mice had a gold content of 15 μg of gold per gram of tissue (P < .001) compared with 4 μg/g of gold observed in splenic tissue. (E) ICP-MS analysis of human epidermal growth factor receptor 2 (HER2)–positive human breast tumors indicated 22 μg of gold per gram of tissue (P = .039).*** = P < .001, * = P < .05, BEC = blank equivalent concentration, DL = detection limit, Temp = temperature, TRA = trastuzumab.

(A) Graph depicts a linear curve with various gold (Au) concentrations, translating into gold per gram of tissue, that confirms the presence of gold in mouse and human tissues. The 1000 µg/mL stock solution of platinum diluted to 0.4 µg/mL with 2% (w/v) nitric acid + 0.5% hydrochloric acid (w/v) is used as an internal standard. (B) Inductively coupled plasma mass spectrometry (ICP-MS) instrument parameters used in the gold analysis. (C) Comparison of the actual versus calculated gold concentrations observed during the ICP-MS analysis. (D) DY36T2Q breast tumors from mice had a gold content of 15 μg of gold per gram of tissue (P < .001) compared with 4 μg/g of gold observed in splenic tissue. (E) ICP-MS analysis of human epidermal growth factor receptor 2 (HER2)–positive human breast tumors indicated 22 μg of gold per gram of tissue (P = .039).*** = P < .001, *= P < .05, BEC = blank equivalent concentration, DL = detection limit, Temp = temperature, TRA = trastuzumab.