Table 1. Increase of entries in ProTherm for different datasets.

Dataset	Release 1.0	Release 2.0	% Increase
Total	3317	5542	67.1
Solvent accessibilitya
Buried	1317	1854	40.8
Partially buried	918	1105	20.4
Exposed	826	1098	32.9
Mutation type
Wild type	429	1599	272.7
Single	2434	3312	36.1
Double	353	480	36.0
Multiple	101	151	49.5
Secondary structure
Helix	1241	1594	28.4
Strand	789	1071	35.7
Turn	242	402	66.1
Coil	846	1078	27.4
Measurement
Circular dichroism	1709	2450	43.4
Fluorescence	1052	1455	38.3
Calorimetry (DSC)	489	1397	185.7
Method
Thermal	1628	2869	76.2
GdnHCl	1094	1697	55.1
Urea	573	942	64.4
Literature
Number of proteins	61	194	218.0
Number of articles	245	599	144.5

^aBuried: ASA <20%; partially buried: 20% < ASA < 50%; exposed: ASA >50%.