Table 5.
Detection of WMCs and CMHs with 7T MRI in Fighters, NHCs, and Patients With TBI
| Nos. of WMCs and CMHs | Fighters (n = 19) | 7T NHCs (n = 21) | Patients with TBI (n = 16a) | p value* | p value** |
|---|---|---|---|---|---|
| Reader 1 | |||||
| Median no. of WMCs overall [IQR] (range) | 3 [1, 14] (0, 57) | 1 [0, 3] (0, 12) | 8 [2, 13] (1, 100) | 0.016 | 0.374 |
| Median no. of subcortical WMCs [IQR] (range) | 3 [1, 8] (0, 19) | 1 [0, 2] (0, 12) | 4 [1, 12] (0, 100) | 0.017 | 0.613 |
| Median no. of periventricular WMCs [IQR] (range) | 0 [0, 1] (0, 38) | 0 [0, 0] (0, 4) | 0 [0, 2] (0, 4) | 0.315 | 0.755 |
| Median no. of CMHs [IQR] (range) | 0 [0, 0] (0, 2) | 0 [0, 0] (0, 1) | 0 [0, 1] (0, 30) | 0.252 | 0.207 |
| Reader 2 | |||||
| Median no. of WMCs overall [IQR] (range) | 3 [2, 14] (0, 46) | 1 [0, 3] (0, 15) | 7 [2, 16] (0, 167) | 0.004 | 0.497 |
| Median no. of subcortical WMCs [IQR] (range) | 3 [1, 12] (0, 37) | 1 [0, 2] (0, 15) | 6 [2, 16] (0, 167) | 0.007 | 0.577 |
| Median no. of periventricular WMCs [IQR] (range) | 0 [0, 0] (0, 9) | 0 [0, 0] (0, 1) | 0 [0, 1] (0, 3) | 0.266 | 0.591 |
| Median no. of CMHs [IQR] (range) | 0 [0, 0] (0, 9) | 0 [0, 0] (0, 1) | 0 [0, 1] (0, 45) | 0.120 | 0.289 |
*
Fighters versus NHCs.
**
Fighters versus patients with TBI.
a
Only 15 patients with TBI were assessed for WMCs.
WMCs, white matter changes; CMHs, cerebral microhemorrhages; T, Tesla; MRI, magnetic resonance imaging; NHCs, normal healthy controls; TBI, head trauma; IQR, interquartile range.