Fig. 7.

(a) A schematic drawing to show two concurrent metabolic-hemodynamic events occuring within cerebral tissue in response to tPBM.⁴⁷ (b) An illustration to depict bilateral prefrontal connectivity between the ipsilateral and contralateral forehead with respect to the tPBM delivery side. On each lateral side, a piece of blood vessel is surrounded with three anatomical components that facilitate three spontaneous ISO (i.e., endogenic, neurogenic, and myogenic) rhythms, respectively, as labeled on the left side of the panel. This panel demonstrates that either 800- or 850-nm laser enables ipsilateral increases in concentration of oxidized CCO (i.e., $\mathrm{\Delta }{[\mathrm{CCO}]}_{\mathrm{oxi}}$) and NO, both of which alter ISO actions on the contralateral side through bCON at different ISOs. (c) This panel demonstrates uCOP between $\mathrm{\Delta }{[\mathrm{CCO}]}_{\mathrm{oxi}}$ and $\mathrm{\Delta }[\mathrm{HbO}]$ on the stimulation side, indicating that tPBM enhances unilateral metabolic and vascular coupling on the stimulation site and side.