Table 2.

Candidate pathways that are related to UVJ epithelial fold formation.

Stage	KEGG	Count	Gene list
S2 vs. S1	ECM–receptor interaction	19	CD36, COL2A1, COL9A2, ENSGALG00000003283, ENSGALG00000010316, ENSGALG00000019761, ENSGALG00000042388, FREM1, FREM2, HSPG2, ITGA11, ITGA8, ITGB6, ITGB8, LAMA1, LAMA4, LAMB2, NPNT, VTN
S2 vs. S1	TGF-beta signaling pathway	20	ACVR2B, BMP2, BMP4, BMPR2, CDKN2B, CHRD, ENSGALG00000012055, GREM1, ID1, ID4, INHBA, INHBB, LTBP1, MYC, RGMA, SMAD2Z, SMAD9, TGFB2, TGFBR2, TGIF2
S2 vs. S1	Cytokine–cytokine receptor interaction	34	ACVR2B, BMP2, BMP4, BMPR2, CCL17, CNTF, CNTFR, CSF3R, CXCL12, CXCL14, CXCR4, EDA2R, ENSGALG00000012055, GDF10, GDF8, GHR, IL11RA, IL12A, IL12B, IL13RA2, IL19, IL20RA, IL6R, INHBA, INHBB, NGFR, TGFB2, TGFBR2, THPO, TNFRSF10B, TNFRSF13B, TNFRSF1B, TNFSF13B, TNFSF15
S2 vs. S1	Cell adhesion molecules (CAMs)	21	BLB1, CD99, CDH2, CLDN16, CLDN19, CLDN8, CNTNAP1, ENSGALG00000005257, ENSGALG00000009355, ENSGALG00000029002, ITGA8, ITGB8, JAM2, NCAM1, NFASC, NLGN4Y, NRXN1, NTNG1, NTNG2, SDC3, VCAN
S2 vs. S1	Focal adhesion	31	BCL2, CAPN2, COL2A1, COL9A2, ENSGALG00000003283, ENSGALG00000010335, ENSGALG00000019761, ENSGALG00000034605, ENSGALG00000042388, HGF, ITGA11, ITGA8, ITGB6, ITGB8, JUN, LAMA1, LAMA4, LAMB2, MYL10, MYL9, MYLK, PARVA, PARVB, PDGFA, PDGFB, PDGFC, PDGFRA, PRKCA, RASGRF1, SRC, VTN
S2 vs. S1	Wnt signaling pathway	24	AXIN2, ENSGALG00000028041, GPC4, JUN, LEF1, LGR5, MYC, NKD1, PRICKLE1, PRKCA, ROR1, ROR2, RSPO3, SFRP1, SFRP2, TCF7, WIF1, WISP1, WNT11, WNT16, WNT2B, WNT6, WNT7A, WNT9A
S3 vs. S2	Cell cycle	29	BUB1, BUB1B, CCNA1, CCNA2, CCNB1, CCNB3, CCNE2, CDC20, CDC7, CDK1, CDK2, CDKN2C, CHEK1, E2F1, ESPL1, GADD45G, MAD2L1, MCM2, MCM3, MCM4, MCM5, MCM6, ORC1, PLK1, PTTG2, RB1, TFDP1, TTK, WEE1
S3 vs. S2	ECM–receptor interaction	18	CD36, COL1A2, COL4A1, COL6A1, COL6A2, COL6A3, ENSGALG00000002389, ENSGALG00000008141, ENSGALG00000042388, HMMR, ITGA2, ITGB6, LAMA4, SPP1, TNC, TNR, VTN, VWF