Table 5.
Stratified analyses of the IRS2 polymorphisms on CRC risk.
| SNP | location | Genotype | Association results | Tumor site | Function | Ref | |
|---|---|---|---|---|---|---|---|
| OR (95% CI) | P-Value | ||||||
| rs1805097G>A | Exon | GG | 1.0 | NR | Colon | An association of GA genotype with risk of CRC | (32) |
| 1.0 | Rectal | ||||||
| GA | 0.8 (0.6-0.9) | Colon | |||||
| 1.0 (0.9-1.3) | Rectal | ||||||
| AA | 1.0 (0.7-1.3) | Colon | |||||
| 0.9 (0.7-1.2) | Rectal | ||||||
| GG | 1.0 | 0.451 | CRC | No significant association with risk of CRC | (36) | ||
| GA | 1.15 (0.89–1.48) | ||||||
| AA | 0.97 (0.68–1.38) | ||||||
| GG | 1.0 | NR | CRC | No significant association with risk of CRC | (45) | ||
| GA | 0.76 (0.48–1.19) | ||||||
| AA | 1.11 (0.58–2.11) | ||||||
| GG | 1.0 | NR | CRC | No significant association with risk of CRC | (41) | ||
| GA | 1.04 (0.71–1.51) | 0.854 | |||||
| AA | 0.97 (0.56–1.66) | 0.898 | |||||
| GG (M) | 1.15 (0.90, 1.47)* | 0.20 | CRC | No significant association with risk of CRC | (21) | ||
| GG (F) | 1.07 (0.82, 1.40) * | 0.51 | |||||
| GA (M) | 1.07 (0.84, 1.36) * | 0.20 | |||||
| GA (F) | 1.01 (0.77, 1.32) * | 0.51 | |||||
| AA (M) | 1.0 | 0.20 | |||||
| AA (F) | 1.0 | 0.51 | |||||
| rs2289046A>G | 3’UTR | AA | 1.0 | NR | CRC | No significant association with risk of CRC | (43) |
| AG | 1.177(0.777–1.782) | 0.441 | |||||
| GG | 0.678 (0.334–1.374) | 0.281 | |||||
| AA (M) | 1.20 (0.93,1.55) | 0.15 | CRC | No significant association with risk of CRC | (21) | ||
| AA (F) | 1.03 (0.78,1.34) * | 0.57 | |||||
| AG (M) | 1.13 (0.88, 1.46) * | 0.15 | |||||
| AG (F) | 0.94 (0.72, 1.23) * | 0.57 | |||||
| GG (M) | 1.0 | 0.15 | |||||
| GG (F) | 1.0 | 0.57 | |||||
| rs754204C>T | Intron | CC (M) | 1.0 | 0.14 | CRC | No significant association with risk of CRC | (21) |
| CC (F) | 1.0 | 0.78 | |||||
| TC (M) | 1.08 (0.91, 1.30) * | 0.14 | |||||
| TC (F) | 0,98 (0.81, 1.20) * | 0.78 | |||||
| TT (M) | 1.17 (0.95, 1.45) * | 0.14 | |||||
| TT (F) | 1.04 (0.82, 1.31) * | 0.78 | |||||
| rs4773082T>C | _ | TT (M) | 1.0 | 0.27 | CRC | No significant association with risk of CRC | (21) |
| TT (F) | 1.0 | 0.81 | |||||
| CT (M) | 1.11 (0.93, 1.33) * | 0.27 | |||||
| CT (F) | 1.00 (0.82,1.23) * | 0.81 | |||||
| CC (M) | 1.12 (0.89, 1.41) * | 0.27 | |||||
| CC (F) | 1.03 (0.80, 1.33) * | 0.81 | |||||
CRC, Colorectal cancer; M, Male; F, Female; NR, Not Reported.
*Hazard Ratio (HR); (-), Not Reported.