Table 6.
Association between IGF1 pathway genes polymorphisms and CRC risk.
| Gene | SNP | Studies (N) | Cases (N) | Controls (N) | Genotype | OR (95% CI) | P |
|---|---|---|---|---|---|---|---|
| IGF1 | 969(CA) | 7 (19, 30, 32–35, 51) | 7,024 | 8,519 | CA(19)/CA(19) | 0.976 (0.85-1.11) | 0.721 |
| CA(19)/non(19) | 0.934 (0.72-1.19) | 0.587 | |||||
| non(19)/non(19) | 1 (0.92-1.09) | 0.864 | |||||
| rs6214C>T | 5 (38–40, 43, 49) | 1,035 | 2,726 | CC | 0.43 (0.21-0.87) | 0.019 | |
| CT | 0.97 (0.64-1.47) | 0.879 | |||||
| TT | 1.37 (0.83-2.26) | 0.216 | |||||
| rs35767C>T | 6 (35), 23, 38, 39, 46, 50) | 3,434 | 5,698 | CC | 0.94 (0.57-1.56) | 0.821 | |
| CT | 1.01 (0.70-1.44) | 0.968 | |||||
| TT | 2.29 (0.76-6.89) | 0.139 | |||||
| IRS1 | rs1801278G>A | 5 (32, 34, 35, 41, 44) | 5,371 | 6,255 | AA | 0.75 (0.17-3.33) | 0.712 |
| GA | 0.74 (0.58-0.94) | 0.016 | |||||
| GG | 1.06 (0.82-1.37) | 0.644 | |||||
| IRS2 | rs1805097G>A | 5 (32, 34, 35, 41, 45) | 5,220 | 6,014 | AA | 0.94 (0.84-1.06) | 0.358 |
| GA | 0.83 (0.71-0.96) | 0.013 | |||||
| GG | 0.96 (0.84-1.10) | 0.627 |
N, number; SNP, single nucleotide polymorphism, OR, odds ratio; CI, confidence interval; P, P-value.The bold values show P-value lower than 0.05 that is statistically significant.