Table 1. Morphological and hemodynamic parameters for different tumour networks with varying degrees of necrosis.

Parameter	Unit	Non-necrotic	Necrotic (3%)	Necrotic (26%)	Literature data	Reference
Morphological parameter
Tumour tissue volume	mm3	14.137	14.137	14.137	−	−
Vascular density	%	0.250	0.245	0.226	0.15−1.25	Kuszyk et al. 2001; Nagy et al. 2012; Sitohy et al. 2012
Length density	mm/mm3	10.675	9.740	9.067	10−72	Kim et al. 2012
Surface area to volume ratio (vascular) (S/V)	mm2/mm3	216.677	211.224	210.328	122−376	Chugh et al. 2009
Maximum extravascular diffusion distance (R)	μm	172.683	180.779	187.371	30−250	Konerding et al. 2001
Mean vessel diameter	μm	16.074	16.833	16.776	5−225	Hashizume et al. 2000; Less et al. 1991
Mean vessel length	mm	0.191	0.188	0.189	0.06−0.3	Less et al. 1991; Pathak et al. 2011
Hemodynamic parameter
Mean flow	nL/min	2.163	1.704	1.379	−	−
Mean velocity	mm/s	0.233	0.209	0.171	0.1−25	Brizel et al. 1993; Kamoun et al. 2010
Shear stress	Pa	0.699	0.661	0.543	1−10	Pries et al. 2001