Table 3.
Hazard ratios (95% confidence interval) for the association of polygenic risk scores and incident atherosclerotic cardiovascular disease, coronary heart disease and stroke overall and stratified by sex and race/ethnicity.
| ASCVD | CHD | Stroke | |||||||
|---|---|---|---|---|---|---|---|---|---|
|
|
|
|
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| Model 1 | Model 2 | Model 3 | Model 1 | Model 2 | Model 3 | Model 1 | Model 2 | Model 3 | |
| Overall | |||||||||
| ASCVD PRS | 1.77 (1.20,2.60) | 1.70 (1.16,2.49) | 1.63 (1.11,2.39) | 1.61 (0.98,2.66) | 1.54 (0.94,2.53) | 1.45 (0.88,2.38) | 1.77 (0.99,3.17) | 1.72 (0.96,3.06) | 1.71 (0.95,3.06) |
| CHD PRS | 0.99 (0.66,1.51) | 0.98 (0.65,1.49) | 0.94 (0.62,1.43) | 0.92 (0.54,1.55) | 0.91 (0.54,1.53) | 0.87 (0.51,1.47) | 1.05 (0.55,2.00) | 1.06 (0.55,2.02) | 1.04 (0.54,1.98) |
| Stroke PRS | 1.84 (1.27,2.68) | 1.88 (1.29,2.73) | 1.84 (1.27,2.68) | 1.87 (1.10,3.18) | 1.86 (1.09,3.18) | 1.79 (1.05,3.06) | 1.91 (1.16,3.15) | 1.97 (1.20,3.24) | 1.96 (1.19,3.23) |
| Men | |||||||||
| ASCVD PRS | 1.29 (0.68,2.47) | 1.32 (0.69,2.50) | 1.29 (0.68,2.45) | 1.08 (0.48,2.43) | 1.13 (0.51,2.54) | 1.11 (0.50,2.49) | 1.77 (0.62,5.04) | 1.76 (0.63,4.90) | 1.74 (0.62,4.89) |
| CHD PRS | 0.77 (0.40,1.47) | 0.77 (0.40,1.48) | 0.77 (0.40,1.46) | 0.66 (0.30,1.47) | 0.68 (0.31,1.52) | 0.68 (0.30,1.50) | 0.98 (0.32,2.99) | 1.05 (0.35,3.10) | 1.09 (0.36,3.29) |
| Stroke PRS | 0.82 (0.43,1.54) | 0.76 (0.40,1.45) | 0.76 (0.40,1.44) | 0.57 (0.22,1.46) | 0.54 (0.21,1.38) | 0.53 (0.21,1.36) | 1.30 (0.56,2.99) | 1.25 (0.54,2.91) | 1.25 (0.54,2.91) |
| Women | |||||||||
| ASCVD PRS | 2.04 (1.24,3.35) | 1.96 (1.20,3.21) | 1.83 (1.11,3.02) | 2.01 (1.04,3.07) | 1.90 (0.99,3.64) | 1.68 (0.87,3.25) | 1.77 (0.86,3.61) | 1.70 (0.84,3.47) | 1.70 (0.83,3.49) |
| CHD PRS | 1.23 (0.72,2.11) | 1.22 (0.71,2.08) | 1.13 (0.66,1.94) | 1.22 (0.60,2.47) | 1.18 (0.58,2.39) | 1.08 (0.53,2.21) | 1.13 (0.52,2.44) | 1.13 (0.52,2.43) | 1.08 (0.50,2.35) |
| Stroke PRS | 2.90 (1.81,4.65) | 3.10 (1.93,4.98) | 3.03 (1.88,4.87) | 3.54 (1.77,7.07) | 3.60 (1.80,7.20) | 3.42 (1.71,6.83) | 2.50 (1.35,4.64) | 2.79 (1.49,5.23) | 2.78 (1.48,5.19) |
| Whites | |||||||||
| ASCVD PRS | 1.36 (0.76,2.43) | 1.34 (0.74,2.40) | 1.23 (0.68,2.21) | 1.61 (0.81,3.21) | 1.58 (0.79,3.14) | 1.41 (0.70,2.83) | 1.05 (0.37,2.96) | 1.03 (0.37,2.91) | 0.97 (0.35,2.75) |
| CHD PRS | 0.91 (0.49,1.68) | 0.90 (0.49,1.67) | 0.85 (0.46,1.57) | 1.12 (0.53,2.35) | 1.11 (0.53,2.34) | 0.98 (0.46,2.08) | 0.73 (0.27,1.97) | 0.73 (0.27,1.97) | 0.73 (0.27,1.99) |
| Stroke PRS | 1.57 (0.84,2.91) | 1.53 (0.82,2.84) | 1.49 (0.80,2.78) | 2.23 (1.02,2.91) | 2.15 (0.98,4.72) | 2.06 (0.94,4.54) | 1.17 (0.47,2.92) | 1.16 (0.46,2.89) | 1.14 (0.46,2.87) |
| Non-Whites | |||||||||
| ASCVD PRS | 2.12 (1.28,3.51) | 2.11 (1.29,3.46) | 2.09 (1.27,3.43) | 1.09 (0.53,2.21) | 1.12 (0.57,2.23) | 1.10 (0.55,2.18) | 3.64 (1.80,7.34) | 3.50 (1.75,6.99) | 3.69 (1.83,7.42) |
| CHD PRS | 1.31 (0.77,2.24) | 1.24 (0.73,2.11) | 1.23 (0.73,2.10) | 0.87 (0.41,1.85) | 0.82 (0.41,1.85) | 0.82 (0.39,1.74) | 1.85 (0.88,3.91) | 1.81 (0.87,3.75) | 1.89 (0.90,3.94) |
| Stroke PRS | 1.90 (1.21,2.96) | 2.00 (1.28,3.11) | 1.97 (1.26,3.07) | 1.51 (0.78,2.93) | 1.56 (0.81,3.01) | 1.52 (0.79,2.92) | 2.27 (1.25,4.11) | 2.40 (1.33,4.33) | 2.39 (1.32,4.32) |
Abbreviations: PRS (polygenic risk score); ASCVD (atherosclerotic cardiovascular disease), CHD (coronary heart disease); PC (principal component).
Model 1: age, sex, race/ethnicity, PC1-PC5.
Model 2: age, sex, race/ethnicity, principal components 1–5, education, Pooled Cohort Equations.
Model 3: age, sex, race/ethnicity, principal components 1–5, education, Pooled Cohort Equations, family history of premature coronary heart disease. Sx was not adjusted for in sex-stratified analyses.
Bolded items are significant.