Table 4.

Univariable and multivariable analysis of the pathological response

	Univariable analysis		Multivariable analysis
	OR (95%CI)	P	OR (95%CI)	P
Gender (Female)	0.721 (0.353, 1.474)	0.370
Age(≥65yr)	0.760 (0.355, 1.626)	0.479
Tumor location		0.444
Lower third	1
Middle third	0.892 (0.344, 2.313)	0.814
UGEJ	1.450 (0.618, 3.401)	0.393
Diffuse	2.526 (0.457, 13.964)	0.288
Tumour size (≥5cm)	6.052 (3.052, 12.101)	<0.001	4.397 (1.190, 16.249)	0.026
ypT(3-4)	30.600 (10.840, 86.379)	<0.001	6.260 (1.124, 34.867)	0.036
ypN		<0.001		0.320
0	1		1
1	1.429 (0.600, 3.404)	0.420	0.454 (0.044, 4.663)	0.506
2	6.452 (2.012, 20.690)	0.002	1.428 (0.065, 31.308)	0.821
3	4.473 (1.861, 10.753)	<0.001	0.228 (0.012, 4.397)	0.327
ypTNM (III)	6.364 (3.147, 12.869)	<0.001	1.891 (0.139, 25.676)	0.632
Histological types	2.275 (1.135, 4.559)	0.020	2.231 (0.598, 8.317)	0.232
Lauren classification	1.663 (0.874, 3.162)	0.121
Degree of differentiation	4.336 (1.986, 9.599)	<0.001	1.718 (0.399, 7.398)	0.468
Vascular or lymphatic invasion	3.575 (1.400, 9.127)	0.008	3.104 (0.518, 18.588)	0.215
Nerve invasion	4.007 (1.466, 10.956)	0.007	1.838 (0.351, 9.622)	0.471
CAF markers
FAP (+)	24.826 (7.326, 84.128)	<0.001	16.905 (2.468,115.810)	0.004
CD10 (+)	20.602 (2.731, 155.415)	0.003	19.022 (0.506,715.246)	0.111
GPR77 (+)	12.258 (1.601, 93.825)	0.016	3.365 (0.131, 86.710)	0.464
EMT markers
N-cadherin (+)	2.847 (1.386, 5.849)	0.004	0.512 (0.125, 2.093)	0.351
Snail1 (+)	2.983 (1.329, 6.697)	0.008	0.521 (0.108, 2.510)	0.416
Twist1 (+)	10.174 (4.404, 23.506)	<0.001	14.238 (3.020, 67.130)	0.001
CSC markers
ALDH1 (+)	2.024 (1.052,3.892)	0.035	0.844 (0.237, 3.005)	0.794
LGR5 (+)	2.796 (1.456,5.368)	0.002	1.861 (0.404, 8.583)	0.426
CD44 (+)	2.324 (1.200, 4.501)	0.012	0.827 (0.205, 3.333)	0.790

UGEJ Upper third and gastroesophageal junction