Table 5.

Univariable and multivariable analysis for overall survival

	Univariable analysis		Multivariable analysis
	HR (95%CI)	P	HR (95%CI)	P
Gender (Female)	1.474 (0.852, 2.550)	0.165
Age(≥65yr)	1.402 (0.816, 2.406)	0.221
Tumor location		0.008		0.032
Lower third	1		1
Middle third	1.586 (0.898, 2.800)	0.112	1.756 (0.915, 3.369)	0.091
UGEJ	0.712 (0.314, 1.617)	0.417	0.437 (0.159, 1.198)	0.108
Diffuse	3.232 (1.480, 7.055)	0.003	2.220 (0.881, 5.593)	0.091
Tumour size (≥5cm)	3.092 (1.684, 5.680)	<0.001	1.808 (0.812, 4.024)	0.147
ypT (3-4)	7.331 (2.659, 20.215)	<0.001	3.671 (0.995, 13.564)	0.051
ypN (2-3)	3.256 (1.969, 5.385)	<0.001	1.930 (0.709, 5.257)	0.198
ypTNM (III)	4.442 (2.456, 8.036)	<0.001	1.816 (0.854, 3.903)	0.126
Histological types	1.167 (0.716, 1.904)	0.535
Lauren classification	1.925 (1.178, 3.144)	0.009	1.576 (0.814, 3.054)	0.177
Degree of differentiation	2.733 (1.303, 5.731)	0.008	1.679 (0.682, 4.130)	0.259
Vascular or lymphatic invasion	1.901 (1.126, 3.210)	0.016	1.141 (0.571, 2.280)	0.708
Nerve invasion	1.256 (0.716, 2.206)	0.427
Mandard TRG (3-5)	2.861 (1.557, 5.260)	0.001	0.669 (0.297, 1.506)	0.332
CAF markers
FAP (+)	1.843 (1.139, 2.983)	0.013	1.465 (0.652, 3.292)	0.356
CD10 (+)	1.832 (1.053, 3.189)	0.032	0.920 (0.436, 1.944)	0.827
GPR77 (+)	1.329 (0.657, 2.690)	0.429	0.697 (0.291, 1.669)	0.418
EMT markers
N-cadherin (+)	2.158 (1.334, 3.490)	0.002	1.908 (1.057, 3.443)	0.032
Snail1 (+)	1.735 (1.047, 2.876)	0.033	2.081 (1.082, 4.004)	0.028
Twist1 (+)	1.335 (0.827, 2.157)	0.237	0.634 (0.357, 1.128)	0.121
CSC markers
ALDH1 (+)	1.148 (0.685, 1.925)	0.601	0.681 (0.367, 1.265)	0.224
LGR5 (+)	1.473 (0.899, 2.413)	0.124	1.685 (0.916, 3.100)	0.093
CD44 (+)	1.095 (677, 1.772)	0.710	0.627 (0.334, 1.179)	0.147

UGEJ Upper third and gastroesophageal junction