| Chemical |
pH |
Mineralized nanoparticles composed of PEGylated hyaluronic acid (P-HA) as the hydrophilic shell, 5β-cholanic acid as the hydrophobic core, and CaP as the pH-responsive mineral |
ΜΤΧ |
Alam et al. 2017
|
| Hyaluronic acid (HA) coated acid-sensitive polymeric nanoparticles (HAPNPs) composed of egg phosphatidylcholine, polyethylenimine, and PCADK |
Dex |
Yu et al. 2019
|
| Stearic acid-octa-arginine and folic acid decorated PLGA -PK3-based lipid polymeric hybrid nanoparticles (Sta-R8-FA-PPLPNs/MTX) composed of PK3, Folate-PEG-PLGA, egg PC, and Sta-R8 |
ΜΤΧ |
Zhao et al. 2018
|
| Poly(β-amino ester)-graft-poly(ethylene glycol) (PAE-g-PEG) self-assembled into spherical micelles and MTX loaded into the hydrophobic core of micelles |
ΜΤΧ |
Moon et al. 2020
|
| Multifunctional FA receptor-targeting and pH-responsive nanocarriers composed of lipids, PEG-PLGA forming a hydrophilic shell, folic acid (FA) around the hydrophilic shell as a targeting ligand, and poly (cyclohexane-1,4-diylacetone dimethylene ketal) (PCADK) and PLGA as a hydrophobic core. PCADK also as a pH-responsive material |
ΜΤΧ |
Zhao et al. 2017
|
| Modular pH-sensitive acetone-based ketal-linked prodrugs of dexamethasone (AKP-dexs) nanoparticles |
Dex |
Xu et al. 2020
|
| Physical |
NIR |
RGD-attached gold (Au) half-shell nanoparticles containing methotrexate (MTX), RGD peptide as targeting moiety for inflammation |
ΜΤΧ |
Lee et al. 2013
|
| Biological |
Redox (ROS) |
Folate conjugated to PEC 100 monostearate as film-forming material, and methotrexate (MTX) and catalase (CAT) co-encapsulated liposomes (FOL-MTX&CAT-L) |
ΜΤΧ |
Chen et al. 2019b
|
| Combined |
Temperature and pH |
Methotrexate (MTX) and gold (Au) nanoparticles incorporated in the pegylated-poly(DL-lactic-co-glycolic acid) nanospheres
|
MTX |
Lima and Reis 2015
|
| NIR and external magnetic field |
MTX-loaded poly(lactic-co-glycolic acid) (PLGA) gold (Au) / iron (Fe) / gold (Au) half-shell nanoparticles conjugated with arginine-glycine-aspartic acid (RGD) |
MTX |
Kim et al. 2015
|
