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. Author manuscript; available in PMC: 2023 Jun 5.
Published in final edited form as: Exp Eye Res. 2022 Jul 31;223:109198. doi: 10.1016/j.exer.2022.109198

Fig. 5. Innate immunity is necessary for uveitis in unprimed animals while adaptive immunity is necessary for increased uveitis severity and duration in primed animals.

Fig. 5.

OCT inflammation score was compared in wild type, RAG-2 deficient, and MyD88 deficient animals in the primed (A,C) and unprimed (B, D) models. Symbols for wild type animals shown in black and white, RAG-2 deficient indicated by cyan squares, and MyD88 deficient indicated by pink triangles. Bar indicates mean score. Comparison performed with Kruskal Wallis test with Dunn’s multiple comparisons. (E) In wild type animals, twelve vitreous cytokines were significantly increased in primed (P) compared to unprimed (P) animals on day 1. In primed RAG-2 animals, vitreous cytokines were decreased when compared to wild-type primed animals, and not significantly different when compared to unprimed wild-type animals. *p < 0.5. **p < 0.01, ***p < 0.001,****p < 0.0001. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)