TABLE 1.
Extrapolated Human Radiation Dose Estimates for [225Ac]Ac-Ofatumumab
| Organ | Equivalent dose (mSv/MBq) |
|---|---|
| Adrenals | 400 |
| Bladder wall | 275 |
| Brain | 84 |
| Breast | 260 |
| Gallbladder | 235 |
| Heart wall | 1,919 |
| Intestine, small | 247 |
| Intestine, large, lower | 260 |
| Intestine, large, upper | 251 |
| Kidney | 1,187 |
| Liver | 1,833 |
| Lung | 1,076 |
| Marrow, red | 1,620 |
| Muscle | 313 |
| Ovaries | 943 |
| Pancreas | 507 |
| Skin | 260 |
| Stomach wall | 240 |
| Spleen | 1,803 |
| Thymus | 638 |
| Thyroid | 517 |
| Uterus | 1,446 |
| Effective dose | 883 |
| Effective dose equivalent | 1,496 |
Mean absorbed doses after injection of [225Ac]Ac-ofatumumab into mice, extrapolated to adult human female model.