Table 1. Baseline characteristics of the patients stratified by ARC-HBR status.

	HBR+ N=663	HBR− N=154	p-value
Gender, female	420 (66.3%)	113 (73.4%)	0.09
Age (yrs)	83.5±4.3	82.1±4.0	<0.0001
BMI (kg/m²)	26.4±5.0	27.5±5.0	0.37
Symptoms
NYHA Class III or IV	424 (67.0%)	87 (56.5%)	0.02
CCS Class III or IV	30 (4.7%)	10 (6.5%)	0.41
Syncope	72 (11.4%)	19 (12.3%)	0.78
STS predicted risk of mortality (%)	4.9±2.9	3.3±2.1	<0.0001
Medical conditions and medical history
Diabetes	189 (29.9%)	32 (20.8%)	0.028
Dyslipidaemia	326 (51.5%)	78 (50.7%)	0.86
Hypertension	547 (86.4%)	129 (83.8%)	0.44
Current smoker	22 (3.5%)	5 (3.3%)	>0.99
Coronary artery disease	267 (42.2%)	52 (33.7%)	0.07
COPD	77 (12.2%)	15 (9.7%)	0.49
Extracranial cerebral artery disease	33 (5.2%)	7 (4.6%)	0.84
Peripheral artery disease	61 (9.6%)	10 (6.5%)	0.27
Dialysis	5 (0.8%)	0 (0.0%)	0.59
History of atrial fibrillation	252 (39.8%)	12 (7.8%)	<0.001
Previous pacemaker implantation	66 (10.4%)	8 (5.2%)	0.046
History of myocardial infarction	54 (8.5%)	12 (7.8%)	0.87
History of PCI	164 (25.9%)	38 (24.7%)	0.84
History of cardiac surgery	40 (6.3%)	4 (2.6%)	0.08
Previous aortic valvuloplasty	11 (1.7%)	1 (0.6%)	0.48
Prior cerebrovascular accident	99 (15.6%)	0 (0.0%)	<0.001
CT findings
Aortic annulus perimeter (mm)	74±5	74±5	0.18
Aortic annulus area (mm²)	423±56	420±55	0.50
Area-derived diameter (mm)	23 (22-24)	23 (22-25)	0.98
Number of events (percentages). Mean±standard deviation or median (Q1-Q3). BMI: body mass index; CCS: Canadian Cardiovascular Society; COPD: chronic obstructive pulmonary disease; CT: computed tomography; HBR: high bleeding risk; NYHA: New York Heart Association; PCI: percutaneous coronary intervention; STS: Society of Thoracic Surgeons