Table 1. Baseline characteristics of the total study population and across the different groups defined by normal/abnormal CFR and MR.
| Total | CFR ≥2.5 | CFR <2.5 | p-value across CFR groups | |||||
|---|---|---|---|---|---|---|---|---|
| MR low | MR high | p-value | MR low | MR high | p-value | |||
| Patients | N=1,102 | N=420 | N=112 | N=344 | N=226 | |||
| Demographics | ||||||||
| Age, yrs | 63 (62-64) | 61 (60-62) | 62 (60-64) | 0.336 | 64 (63-65) | 66 (64-67) | 0.322 | <0.005 |
| Male sex, % | 69 (62-73) | 69 (65-74) | 72 (62-79) | 0.650 | 64 (59-69) | 72 (65-77) | 0.427 | 0.105 |
| BMI, kg/m2 | 26 (25–26) | 25 (25–25) | 26 (26–27) | 0.007 | 26 (25–26) | 26 (25–26) | 0.523 | 0.263 |
| LVEF, % | 61 (59–62) | 62 (61–63) | 62 (60–63) | 0.966 | 60 (59–61) | 60 (60–62) | 0.976 | 0.005 |
| Coronary risk factors | ||||||||
| Hypertension, % | 58 (52-63) | 52 (47-57) | 62 (52-71) | 0.147 | 58 (53-63) | 66 (59-72) | 0.044 | 0.008 |
| Diabetes, % | 24 (19-29) | 22 (18-26) | 22 (15-32) | 0.712 | 26 (21-31) | 24 (19-30) | 0.645 | 0.158 |
| Hyperlipidaemia, % | 62 (57-68) | 60 (55-65) | 56 (46-65) | 0.463 | 65 (59-69) | 65 (59-71) | 0.735 | 0.171 |
| Positive family history, % | 37 (32-47) | 35 (31-40) | 35 (26-46) | 0.575 | 37 (32-43) | 41 (34-48) | 0.425 | 0.211 |
| Current smoking, % | 22 (17-27) | 22 (18-27) | 24 (16-34) | 0.902 | 21 (17-26) | 22 (17-28) | 0.620 | 0.577 |
| Prior myocardial infarction, % | 14 (11-19) | 12 (9-16) | 14 (8-22) | 0.643 | 16 (13-21) | 17 (13-23) | 0.749 | 0.020 |
| Prior coronary intervention, % | 21 (17-27) | 20 (16-25) | 20 (13-29) | 0.702 | 24 (20-29) | 18 (13-24) | 0.390 | 0.560 |
| Medication | ||||||||
| Aspirin, % | 78 (73-83) | 80 (76-84) | 78 (68-85) | 0.231 | 77 (72-82) | 78 (71-83) | 0.986 | 0.597 |
| ACE inhibitor, % | 38 (33-44) | 35 (30-39) | 46 (36-56) | 0.124 | 38 (33-44) | 40 (34-47) | 0.533 | 0.287 |
| Beta blocker, % | 46 (40-52) | 43 (39-48) | 41 (32-52) | 0.455 | 47 (41-53) | 52 (45-59) | 0.541 | 0.058 |
| Calcium antagonist, % | 39 (33-45) | 36 (32-41) | 41 (32-52) | 0.388 | 38 (32-43) | 44 (37-51) | 0.171 | 0.345 |
| Nitrates, % | 36 (30-42) | 36 (32-42) | 31 (22-41) | 0.501 | 35 (30-41) | 39 (32-46) | 0.453 | 0.648 |
| Data presented as n (%) or mean±standard deviation. BMI: body mass index; CFR: coronary flow reserve; LVEF: left ventricular ejection fraction; MR: minimal micorvascular resistance | ||||||||