Table 2. Coronary angiography characteristics of the total study population and across the different groups defined by abnormal and normal CFR and MR.
| Total | CFR ≥2.5 | CFR <2.5 | p-value across CFR groups | |||||
|---|---|---|---|---|---|---|---|---|
| MR low | MR high | p-value | MR low | MR high | p-value | |||
| Vessels | N=1,562 | N=618 | N=175 | N=487 | N=282 | |||
| Interrogated vessel | ||||||||
| LAD, (%) | 779 (49) | 332 (53) | 72 (39) | 0.019 | 234 (46) | 141 (46) | 0.910 | 0.123 |
| RCX, (%) | 388 (25) | 129 (21) | 37 (24) | 0.932 | 151 (33) | 71 (25) | 0.136 | 0.090 |
| RCA, (%) | 386 (25) | 155 (26) | 65 (37) | 0.010 | 99 (20) | 67 (28) | 0.126 | 0.084 |
| Unknown, (%) | 9 (1) | 2 (0) | 1 (0) | n/a | 3 (1) | 3 (1) | n/a | |
| Quantitative analysis | ||||||||
| Diameter stenosis, % | 45.5±17.0 | 42.9±16.6 | 42.9±17.1 | 0.983 | 46.7±17.0 | 51.0±16.6 | 0.001 | <0.005 |
| Haemodynamic | ||||||||
| bHR | 68.9±11.6 | 67.8±10.9 | 68.5±11.3 | 0.650 | 70.4±12.1 | 69.9±12.4 | 0.756 | 0.019 |
| bPd | 94.9±15.2 | 94.4±14.2 | 99.0±14.6 | <0.005 | 93.4±15.5 | 96.0±16.5 | 0.019 | 0.184 |
| hPd | 81.5±14.9 | 80.5±13.9 | 86.6±12.5 | <0.005 | 79.3±15.5 | 84.1±15.9 | <0.005 | 0.3311 |
| bPa | 98.3±15.0 | 97.6±14.1 | 101.2±13.9 | <0.005 | 97.3±15.5 | 99.7±16.2 | 0.027 | 0.818 |
| hPa | 90.1±15.5 | 89.0±14.9 | 94.4±12.2 | <0.005 | 88.3±16.2 | 93.0±16.5 | <0.005 | 0.889 |
| bAPV | 17.2±7.4 | 15.7±4.9 | 9.86±2.1 | <0.005 | 23.4±8.1 | 14.1±3.7 | <0.005 | <0.005 |
| hAPV | 41.1±15.8 | 48.6±13.8 | 29.6±5.7 | <0.005 | 47.2±15.7 | 27.4±7.4 | <0.005 | <0.005 |
| bTmn | 0.77±0.44 | 0.80±0.29 | 1.43±0.47 | <0.005 | 0.41±0.23 | 0.88±0.39 | <0.005 | <0.005 |
| hTmn | 0.28±0.18 | 0.21±0.06 | 0.41±0.13 | <0.005 | 0.22±0.13 | 0.54±0.26 | <0.005 | <0.005 |
| Physiological metrics | ||||||||
| FFR | 0.90±0.06 | 0.90±0.06 | 0.92±0.06 | <0.005 | 0.89±0.05 | 0.90±0.05 | <0.005 | <0.005 |
| CFR | 2.76±1.10 | 3.65±0.98 | 3.32±0.73 | <0.005 | 1.96±0.40 | 1.87±0.42 | <0.005 | <0.005 |
| HMR | 2.29±0.86 | 1.79±0.38 | 3.00±0.56 | <0.005 | 1.84±0.42 | 3.31±0.79 | <0.005 | <0.005 |
| IMR | 21.8±14.0 | 15.8±4.52 | 34.9±9.68 | <0.005 | 15.76±4.67 | 42.7±21.1 | <0.005 | <0.005 |
| Data presented as n (%) or mean±standard deviation. APV: average peak velocity; b: baseline; CFR: coronary flow reserve; FFR: fractional flow reserve; h: hyperaemic; HMR: hyperaemic microvascular resistance; HR: heart rate; IMR: index of microvascular resistance; LAD: left anterior descending artery; MR: minimal resistance; RCA: right coronary artery; RCX: ramus circumflexus coronary artery; Pa: aortic pressure; Pd: distal pressure; Tmn: mean transit time | ||||||||